Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | v-akt murine thymoma viral oncogene homolog 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0038 | 0.4779 | 0.6195 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0028 | 0.2602 | 0.2485 |
Echinococcus granulosus | nervana 2 | 0.0025 | 0.201 | 0.1885 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.5311 | 1 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0025 | 0.201 | 0.1885 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.458 | 0.4495 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0025 | 0.201 | 0.1885 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.5311 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0028 | 0.2602 | 0.2485 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.458 | 0.4495 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.458 | 0.7747 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.458 | 0.7747 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0025 | 0.207 | 0.5 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0025 | 0.201 | 0.1885 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0025 | 0.201 | 0.1885 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.458 | 0.7747 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0028 | 0.2602 | 0.2485 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.7619 | 1 |
Trypanosoma cruzi | Protein kinase B | 0.0028 | 0.2602 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0028 | 0.2602 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.7619 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.4164 | 0.5371 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.5311 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.7619 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.7619 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.004 | 0.5311 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0025 | 0.201 | 0.1885 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.4164 | 0.5371 |
Entamoeba histolytica | protein kinase, putative | 0.004 | 0.5311 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.004 | 0.5311 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.5311 | 1 |
Giardia lamblia | Kinase, AGC PKA | 0.0025 | 0.207 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.5311 | 1 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0025 | 0.207 | 0.1945 |
Brugia malayi | hypothetical protein | 0.0037 | 0.458 | 0.5929 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.004 | 0.5311 | 0.6907 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.5311 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.458 | 0.4495 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0028 | 0.2602 | 0.164 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0025 | 0.207 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0038 | 0.4779 | 0.836 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0028 | 0.2602 | 0.2485 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0025 | 0.207 | 0.1945 |
Brugia malayi | Protein kinase domain containing protein | 0.004 | 0.5311 | 0.6907 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0028 | 0.2602 | 0.164 |
Echinococcus granulosus | nervana 2 | 0.0025 | 0.201 | 0.1885 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.4164 | 0.4073 |
Echinococcus multilocularis | nervana 2 | 0.0025 | 0.201 | 0.1885 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.458 | 0.7747 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0038 | 0.4779 | 0.6195 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0025 | 0.207 | 0.1945 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.5311 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.458 | 0.4495 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 18 nM | Inhibition of Akt | ChEMBL. | 19497644 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.