Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0315 | 0.2622 | 0.2622 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0378 | 0.3705 | 0.5 |
Echinococcus multilocularis | tumor suppressor p53 binding protein 1 | 0.0315 | 0.2622 | 0.3909 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.2036 | 0.3036 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0555 | 0.6708 | 1 |
Echinococcus granulosus | tumor suppressor p53 binding protein 1 | 0.0315 | 0.2622 | 0.3909 |
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 0.3705 | 0.5 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.1058 | 0.1058 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.2036 | 0.3036 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0555 | 0.6708 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.9 nM | Displacement of [35S]-labeled ligand from VLA4 in human Jurkat cells washed with buffer containing non activating Ca2+ and Mg2+ by competitive binding assay | ChEMBL. | 19713111 |
IC50 (binding) | = 65 nM | Receptor occupancy of VLA4 in whole blood washed with buffer containing non activating Ca2+ and Mg2+ at 37 degC after 3 hrs | ChEMBL. | 19713111 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.