Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 0.3813 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0412 | 0.1171 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3517 | 0.9132 |
Echinococcus multilocularis | tar DNA binding protein | 0.0132 | 0.3517 | 0.3517 |
Onchocerca volvulus | 0.0052 | 0.1136 | 1 | |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0142 | 0.3813 | 0.3813 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 0.3813 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0042 | 0.012 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0412 | 0.0412 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0412 | 0.0412 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.3501 | 0.9083 |
Echinococcus granulosus | tar DNA binding protein | 0.0132 | 0.3517 | 0.3517 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0132 | 0.3501 | 0.3501 |
Loa Loa (eye worm) | TAR-binding protein | 0.0132 | 0.3517 | 1 |
Echinococcus granulosus | lamin | 0.0027 | 0.0412 | 0.0412 |
Brugia malayi | TAR-binding protein | 0.0132 | 0.3517 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0412 | 0.0412 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0412 | 0.1171 |
Brugia malayi | RNA binding protein | 0.0132 | 0.3517 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0132 | 0.3517 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0132 | 0.3517 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1136 | 0.3229 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0412 | 0.1064 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0412 | 0.0412 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0397 | 0.113 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3517 | 0.9132 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3517 | 0.9132 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0412 | 0.0412 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0412 | 0.1171 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0052 | 0.1136 | 0.2128 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3517 | 0.9132 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0412 | 0.1064 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0132 | 0.3517 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3517 | 0.9132 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0132 | 0.3501 | 0.3501 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 25 ug ml-1 | Antifungal activity against Cryptococcus neoformans KCCM 50564 after 1 day by twofold broth dilution method | ChEMBL. | 19733068 |
MIC (functional) | = 50 ug ml-1 | Antifungal activity against Candida albicans Berkout KCCM 50235 after 1 day by twofold broth dilution method | ChEMBL. | 19733068 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.