Detailed information for compound 1075692

Basic information

Technical information
  • TDR Targets ID: 1075692
  • Name: 7-(2-methylpropyl)-6-[4-(phenylmethoxy)phenyl ]-3-(2H-tetrazol-5-yl)pyrazolo[1,5-a]pyrimidi ne
  • MW: 425.486 | Formula: C24H23N7O
  • H donors: 1 H acceptors: 5 LogP: 4.33 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Cc1c(cnc2n1ncc2c1nnn[nH]1)c1ccc(cc1)OCc1ccccc1)C
  • InChi: 1S/C24H23N7O/c1-16(2)12-22-20(13-25-24-21(14-26-31(22)24)23-27-29-30-28-23)18-8-10-19(11-9-18)32-15-17-6-4-3-5-7-17/h3-11,13-14,16H,12,15H2,1-2H3,(H,27,28,29,30)
  • InChiKey: DBWNJRPFMZCMCV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-isobutyl-6-[4-(phenylmethoxy)phenyl]-3-(2H-tetrazol-5-yl)pyrazolo[1,5-a]pyrimidine
  • 6-[4-(benzyloxy)phenyl]-7-isobutyl-3-(2H-tetrazol-5-yl)pyrazolo[1,5-a]pyrimidine
  • 7-(2-methylpropyl)-6-[4-(phenylmethoxy)phenyl]-3-(2H-1,2,3,4-tetrazol-5-yl)pyrazolo[1,5-a]pyrimidine
  • AIDS-352663
  • AIDS352663
  • Pyrazolo[1,5-a]pyrimidine, 7-(2-methylpropyl)-6-[4-(phenylmethoxy)phenyl]-3-(1H-tetrazol-5-yl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.1104 0.3855
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0954 0.2706
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0051 0.2863 0.8121
Schistosoma mansoni intermediate filament proteins 0.0059 0.3526 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.3526 0.3526
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.1759 0.6145
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.332 0.5
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0693 0.1964
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.1759 0.6145
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.332 0.5
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0051 0.2863 0.8623
Schistosoma mansoni hypothetical protein 0.0025 0.0693 0.1964
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0878 0.3066
Plasmodium vivax ataxin-2 like protein, putative 0.0056 0.332 0.5
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0051 0.2863 0.8623
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.3526 0.3526
Trypanosoma brucei target of rapamycin kinase 3, putative 0.004 0.1985 0.5979
Echinococcus multilocularis lamin dm0 0.0059 0.3526 1
Trypanosoma cruzi target of rapamycin kinase 3 0.004 0.1985 0.5979
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.2233 0.78
Loa Loa (eye worm) hypothetical protein 0.0028 0.0954 0.0954
Loa Loa (eye worm) hypothetical protein 0.0056 0.332 0.332
Echinococcus multilocularis musashi 0.0059 0.3526 1
Trypanosoma brucei PAB1-binding protein , putative 0.0056 0.332 1
Echinococcus granulosus lamin dm0 0.0059 0.3526 1
Leishmania major hypothetical protein, conserved 0.0056 0.332 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.1352 0.4722
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.004 0.1985 0.5979
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1982 0.6922
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.1218 0.1218
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0051 0.2863 0.5
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0051 0.2863 0.8623
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.3526 0.3526
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0051 0.2863 0.8623
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0051 0.2863 0.8121
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0954 0.2706
Echinococcus multilocularis lamin 0.0059 0.3526 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.1129 0.3945
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1982 0.6922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0881 0.3078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.1759 0.6145
Loa Loa (eye worm) hypothetical protein 0.0027 0.0863 0.0863
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0878 0.3066
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.1104 0.3855
Brugia malayi intermediate filament protein 0.0059 0.3526 0.3526
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.1759 0.6145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.1445 0.5047
Onchocerca volvulus 0.0059 0.3526 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.332 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0881 0.3078
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0693 0.1964
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.2863 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.1759 0.6145
Brugia malayi hypothetical protein 0.0056 0.332 0.332
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.1129 0.3945
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0051 0.2863 0.5
Echinococcus granulosus lamin 0.0059 0.3526 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.2863 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.3435 0.3435
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1982 0.6922
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1982 0.6922
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.0345 0.1038
Giardia lamblia GTOR 0.0051 0.2863 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1982 0.6922
Echinococcus granulosus intermediate filament protein 0.0059 0.3526 1
Onchocerca volvulus 0.0059 0.3526 0.5
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0051 0.2863 0.8623
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0881 0.3078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.2863 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0051 0.2863 0.2863
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.1759 0.6145
Schistosoma mansoni lamin 0.0059 0.3526 1
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.1218 0.1218
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.1129 0.3945
Brugia malayi hypothetical protein 0.0036 0.1632 0.1632
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0051 0.2863 0.2863
Loa Loa (eye worm) hypothetical protein 0.0027 0.0863 0.0863
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.332 1
Schistosoma mansoni lamin 0.0059 0.3526 1
Toxoplasma gondii LsmAD domain-containing protein 0.0056 0.332 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0878 0.3066
Loa Loa (eye worm) intermediate filament protein 0.0059 0.3526 0.3526
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.1759 0.6145
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0051 0.2863 0.8623
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0593 0.1785
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0881 0.3078
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0051 0.2863 0.8121

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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