Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | peptide deformylase | 0.0233 | 1 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0089 | 0.3174 | 1 |
Echinococcus granulosus | isoleucyl trna synthetase mitochondrial | 0.0027 | 0.0228 | 0.0523 |
Echinococcus granulosus | isoleucyl tRNA synthetase, cytoplasmic | 0.0034 | 0.057 | 1 |
Entamoeba histolytica | isoleucyl-tRNA synthetase, putative | 0.0034 | 0.057 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0233 | 1 | 1 |
Schistosoma mansoni | isoleucine--tRNA ligase | 0.0034 | 0.057 | 1 |
Brugia malayi | isoleucyl-tRNA synthetase family protein | 0.0034 | 0.057 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.057 | 1 |
Mycobacterium ulcerans | peptide deformylase | 0.0233 | 1 | 1 |
Giardia lamblia | Isoleucyl-tRNA synthetase | 0.0034 | 0.057 | 0.5 |
Schistosoma mansoni | isoleucine--tRNA ligase | 0.0034 | 0.057 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0089 | 0.3174 | 1 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0089 | 0.3174 | 1 |
Brugia malayi | isoleucyl-tRNA synthetase | 0.0034 | 0.057 | 1 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0089 | 0.3174 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0228 | 0.0523 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0089 | 0.3174 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0089 | 0.3174 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0089 | 0.3174 | 1 |
Echinococcus multilocularis | isoleucyl tRNA synthetase, mitochondrial | 0.0027 | 0.0228 | 0.0523 |
Loa Loa (eye worm) | isoleucyl-tRNA synthetase | 0.0034 | 0.057 | 1 |
Trichomonas vaginalis | isoleucyl tRNA synthetase, putative | 0.0034 | 0.057 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0233 | 1 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 0.0233 | 1 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0233 | 1 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.0233 | 1 | 1 |
Echinococcus multilocularis | isoleucyl tRNA synthetase, cytoplasmic | 0.0034 | 0.057 | 1 |
Onchocerca volvulus | 0.0027 | 0.0228 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log IC50 (binding) | = 4.13 | Inhibition of dopamine beta hydroxylase | ChEMBL. | 7783140 |
-Log IC50 (binding) | = 4.13 | Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally | ChEMBL. | 2296023 |
IC50 (binding) | = 4.13 | Inhibition of dopamine beta hydroxylase | ChEMBL. | 7783140 |
IC50 (binding) | = 4.13 | Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally | ChEMBL. | 2296023 |
IC50 (binding) | = 4.13 | Inhibition of dopamine beta-hydroxylase (DbetaH) enzyme | ChEMBL. | 9435905 |
Inhibition (binding) | = 67 % | Percent inhibition against bovine Dopamine beta hydroxylase (DBH) at 10E-4 M | ChEMBL. | 3820219 |
Inhibition (binding) | = 67 % | Percent inhibition against bovine Dopamine beta hydroxylase (DBH) at 10E-4 M | ChEMBL. | 3820219 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
4 literature references were collected for this gene.