Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0048 | 0.0681 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.7779 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.0681 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0048 | 0.0681 | 1 |
Onchocerca volvulus | 0.0049 | 0.0736 | 1 | |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0242 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0149 | 0.5528 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0242 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0196 | 0.7779 | 0.7616 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.7779 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0149 | 0.5528 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0036 | 0.0095 | 0.139 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0681 | 0.0592 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0036 | 0.0095 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.7779 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0036 | 0.0095 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0048 | 0.0681 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0196 | 0.7779 | 0.7758 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0149 | 0.5528 | 0.6804 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0048 | 0.0681 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.0736 | 0.0059 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0036 | 0.0095 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0149 | 0.5528 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.5528 | 0.6804 |
Brugia malayi | RNA binding protein | 0.0196 | 0.7779 | 0.7616 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0048 | 0.0681 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.7779 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0048 | 0.0681 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0048 | 0.0681 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0196 | 0.7779 | 0.7758 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0048 | 0.0681 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.0681 | 1 |
Brugia malayi | hypothetical protein | 0.0149 | 0.5528 | 0.5201 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.7779 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0048 | 0.0681 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0196 | 0.7779 | 0.7758 |
Echinococcus multilocularis | tar DNA binding protein | 0.0196 | 0.7779 | 0.5033 |
Entamoeba histolytica | hypothetical protein | 0.0149 | 0.5528 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0048 | 0.0681 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0196 | 0.7779 | 0.5033 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0681 | 0.0592 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0196 | 0.7779 | 0.7616 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0048 | 0.0681 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0048 | 0.0681 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.0681 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0681 | 0.0592 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.