Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0029 | 0.0861 | 0.1063 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0029 | 0.0861 | 0.1063 |
Echinococcus granulosus | glutamate receptor 2 | 0.0029 | 0.0861 | 0.1063 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.2087 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.2761 | 0.2444 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.2368 | 1 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0029 | 0.0861 | 0.1063 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0029 | 0.0861 | 0.1063 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1804 | 0.7103 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0095 | 0.7233 | 0.8937 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.7233 | 0.8937 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.2761 | 0.2444 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0104 | 0.8094 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0024 | 0.0419 | 0.0518 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0024 | 0.0419 | 0.0518 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0029 | 0.0861 | 0.1063 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.01 | 0.7674 | 0.9482 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.2368 | 0.2926 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0029 | 0.0861 | 0.1063 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.2087 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.01 | 0.7674 | 0.9482 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0029 | 0.0861 | 0.1063 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.2368 | 0.2926 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0029 | 0.0861 | 0.1063 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0104 | 0.8094 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0029 | 0.0861 | 0.1063 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.2368 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0024 | 0.0419 | 0.0518 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | > 98 % | Displacement of [3H]astemizole from human recombinant ERG expressed in HEK293 cells at 10 uM | ChEMBL. | 19648014 |
IC50 (functional) | = 19 nM | Antagonist activity at human recombinant NR1/NR2B receptor expressed in frog oocytes assessed as inhibition of glutamate/glycine-induced current by two electrode voltage clamp method | ChEMBL. | 19648014 |
Inhibition (functional) | = 21 % | Antagonist activity at rat recombinant NR1/NR2B receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current at 3 uM by two electrode voltage clamp method relative to control | ChEMBL. | 19648014 |
Inhibition (functional) | = 89 % | Antagonist activity at rat recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current at 3 uM by two electrode voltage clamp method relative to control | ChEMBL. | 19648014 |
Inhibition (functional) | = 91 % | Antagonist activity at rat recombinant NR1/NR2D receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current at 3 uM by two electrode voltage clamp method relative to control | ChEMBL. | 19648014 |
Inhibition (functional) | = 99 % | Antagonist activity at rat recombinant GluR6 expressed in Xenopus laevis oocytes assessed as inhibition of concanavalin A/glutamate-induced current at 3 uM by two electrode voltage clamp method relative to control | ChEMBL. | 19648014 |
Inhibition (functional) | = 102 % | Antagonist activity at rat recombinant GluR1 expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced current at 3 uM by two electrode voltage clamp method relative to control | ChEMBL. | 19648014 |
Inhibition (functional) | = 104 % | Antagonist activity at rat recombinant NR1/NR2C receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current at 3 uM by two electrode voltage clamp method relative to control | ChEMBL. | 19648014 |
Ki (binding) | = 14 nM | Displacement of [3H]astemizole from human recombinant ERG expressed in HEK293 cells | ChEMBL. | 19648014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.