Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.4722 | 0.4688 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.7379 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0603 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.7379 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.4722 | 0.6015 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0004 | 0.0082 | 0.1363 |
Trypanosoma brucei | ISWI complex protein | 0.0003 | 0 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.4722 | 0.4688 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0711 | 0.0651 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0059 | 0.8876 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.4439 | 0.5396 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0191 | 0.0127 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.7379 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.7379 | 0.7362 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.4439 | 0.5381 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.7379 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0004 | 0.0082 | 0.1363 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.7379 | 0.7362 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Onchocerca volvulus | 0.0031 | 0.4439 | 0.5 | |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Plasmodium falciparum | zinc finger protein, putative | 0.0004 | 0.0064 | 0.5 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0004 | 0.0082 | 0.1363 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.1014 | 0.0453 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.7379 | 1 |
Trypanosoma cruzi | ISWI complex protein | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.7379 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.4722 | 0.6015 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0.0064 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.1014 | 0.0453 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0603 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.4439 | 0.4403 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.7379 | 0.7362 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 212 uM | Inhibition of human recombinant DNMT1 expressed in baculovirus-insect cell system by scintillation counting | ChEMBL. | 20006515 |
Inhibition (binding) | = 78 % | Inhibition of human recombinant DNMT1 expressed in baculovirus-insect cell system at 100 uM by scintillation counting | ChEMBL. | 20006515 |
Inhibition (binding) | = 96 % | Inhibition of human recombinant DNMT3B expressed in baculovirus-insect cell system at 100 uM by scintillation counting | ChEMBL. | 20006515 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.