Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | No references | |
Rattus norvegicus | Voltage-gated N-type calcium channel alpha-1B subunit | No references | |
Homo sapiens | calcium channel, voltage-dependent, beta 1 subunit | No references | |
Rattus norvegicus | Voltage-dependent N-type calcium channel alpha1B/alpha2b/beta1b | No references | |
Cavia porcellus | Voltage-dependent L-type calcium channel alpha1C/alpha2delta/beta1b | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Cache domain containing protein | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 1091 aa | 1161 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0193 | 0.1052 | 0.2332 |
Schistosoma mansoni | serine-rich repeat protein | 0.0104 | 0.015 | 0.0259 |
Schistosoma mansoni | high voltage-activated calcium channel beta subunit 2 | 0.0524 | 0.4388 | 1 |
Echinococcus multilocularis | high voltage activated calcium channel beta | 0.0524 | 0.4388 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0443 | 0.3578 | 0.8137 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0093 | 0.0038 | 0.0038 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0443 | 0.3578 | 0.8137 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0202 | 0.1135 | 0.2524 |
Echinococcus granulosus | high voltage activated calcium channel beta | 0.0524 | 0.4388 | 1 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0098 | 0.0083 | 0.0105 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.015 | 0.0259 |
Loa Loa (eye worm) | calcium channel | 0.0093 | 0.0038 | 0.0038 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0202 | 0.1135 | 0.2524 |
Loa Loa (eye worm) | voltage-dependent calcium channel beta 2a subunit | 0.1079 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0038 | 0.0038 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 190 nM | Antagonist activity at rat brain alpha1B/alpha2b/beta1b N-type calcium channel expressed in HEK293 cells assessed as 0 | PATENT. | No reference |
IC50 (binding) | = 966 nM | Antagonist activity at alpha1A/alpha2delta/beta1b P/Q-type calcium channel (unknown origin) expressed in HEK293 cells assessed as 0 | PATENT. | No reference |
IC50 (binding) | = 0.074 uM | Antagonist activity at rat alpha1B N-type Ca2+ channel expressed in HEK293 cells assessed as 0 | PATENT. | No reference |
IC50 (binding) | = 0.1 uM | Antagonist activity at rat alpha1B N-type calcium channel expressed in HEK293 cells assessed as 0 | PATENT. | No reference |
IC50 (binding) | = 19.6 uM | Antagonist activity at alpha1C/alpha2delta/beta1b L-type calcium channel (unknown origin) expressed in HEK293 cells assessed as 0 | PATENT. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.