Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | fatty acid amide hydrolase | Starlite/ChEMBL | References |
Mus musculus | monoglyceride lipase | Starlite/ChEMBL | References |
Mus musculus | abhydrolase domain containing 6 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | epoxide hydrolase 2 | abhydrolase domain containing 6 | 336 aa | 295 aa | 19.7 % |
Trypanosoma cruzi | amidase, putative | fatty acid amide hydrolase | 579 aa | 467 aa | 26.6 % |
Plasmodium vivax | hypothetical protein, conserved | monoglyceride lipase | 258 aa | 241 aa | 22.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0711 | 0.1923 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.0499 | 1 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0.1296 | 1 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0084 | 0.1296 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.1296 | 0.5 |
Leishmania major | monoglyceride lipase, putative | 0.0084 | 0.1296 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.1296 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0.1296 | 0.5 |
Schistosoma mansoni | plexin | 0.0056 | 0.0711 | 0.1923 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0123 | 0.2112 | 1 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0084 | 0.1296 | 0.5 |
Brugia malayi | amidase | 0.0123 | 0.2112 | 1 |
Plasmodium falciparum | esterase, putative | 0.0084 | 0.1296 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.1296 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0.1296 | 0.5 |
Echinococcus multilocularis | plexin a4 | 0.0114 | 0.193 | 0.8953 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1559 | 0.6811 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.2112 | 1 |
Echinococcus granulosus | plexin a4 | 0.0114 | 0.193 | 0.8953 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.1296 | 0.5 |
Schistosoma mansoni | plexin | 0.0097 | 0.1559 | 0.6811 |
Schistosoma mansoni | amidase | 0.0123 | 0.2112 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.2112 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.2112 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.2112 | 1 |
Brugia malayi | plexin A | 0.0114 | 0.193 | 0.8953 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.1296 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.1296 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.2112 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.1296 | 0.5 |
Brugia malayi | Plexin repeat family protein | 0.0097 | 0.1559 | 0.6811 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0.1296 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.1296 | 0.5 |
Onchocerca volvulus | 0.0097 | 0.1559 | 1 | |
Loa Loa (eye worm) | plexin A | 0.0114 | 0.193 | 0.8953 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.1296 | 0.5 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.009 | 0.1425 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0711 | 0.1923 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.1296 | 0.5 |
Plasmodium vivax | PST-A protein | 0.0084 | 0.1296 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 70 nM | Inhibition of MAGL in mouse brain membrane | ChEMBL. | 20099888 |
IC50 (binding) | = 150 nM | Inhibition of ABHD6 in mouse brain membrane | ChEMBL. | 20099888 |
IC50 (binding) | = 380 nM | Inhibition of FAAH in mouse brain membrane | ChEMBL. | 20099888 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.