Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | stearoyl-Coenzyme A desaturase 1 | Starlite/ChEMBL | References |
Homo sapiens | stearoyl-CoA desaturase (delta-9-desaturase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | acyl-CoA desaturase | 0.0205 | 0 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0205 | 0 | 0.5 |
Onchocerca volvulus | 0.0223 | 1 | 0.5 | |
Leishmania major | fatty-acid desaturase, putative | 0.0223 | 1 | 0.5 |
Onchocerca volvulus | 0.0223 | 1 | 0.5 | |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0205 | 0 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0205 | 0 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0223 | 1 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0223 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 0.5 ug.hr/ml | AUC (0 to 8 hrs) in C57BL/6 mouse at 20 mg/kg, po | ChEMBL. | 19926281 |
CL (ADMET) | = 42 ml/min.kg | Clearance in C57BL/6 mouse at 5 mg/kg, iv | ChEMBL. | 19926281 |
Cmax (ADMET) | = 0.3 ug ml-1 | Cmax in C57BL/6 mouse at 20 mg/kg, po | ChEMBL. | 19926281 |
F (ADMET) | = 6 % | Oral bioavailability in C57BL/6 mouse at 20 mg/kg | ChEMBL. | 19926281 |
IC50 (binding) | = 7 nM | Inhibition of Scd1 in mouse liver microsomes assessed as conversion of [14C]stearate to [14C]oleate pretreated for 10 mins measured after 60 mins | ChEMBL. | 19926281 |
IC50 (binding) | = 15 nM | Inhibition of Scd1 in human HEK293A cell microsomes assessed as conversion of [14C]stearate to [14C]oleate pretreated for 10 mins measured after 60 mins | ChEMBL. | 19926281 |
IC50 (binding) | = 51 nM | Inhibition of human Scd1 expressed in HEK293A cells assessed as conversion of [14C]stearate to [14C]oleate pretreated for 30 mins measured after 4 hrs | ChEMBL. | 19926281 |
IC50 (binding) | = 0.007 uM | Inhibition of SCD1 in human 293A cells assessed as conversion of [14C]stearate to [14C]oleate after 60 mins in presence of S9 microsomal fraction | ChEMBL. | 20006498 |
IC50 (binding) | = 0.015 uM | Inhibition of SCD1 in mouse microsomal liver S9 microsomal fraction assessed as conversion of [14C]stearate to [14C]oleate after 60 mins | ChEMBL. | 20006498 |
ID50 (functional) | = 12 mg kg-1 | Inhibition of Scd1 in po dosed db/db mouse assessed as [14C]oleate to [14C]stearate ratio in liver administered 2 hrs before [14C]stearate challenge measured after 1 hr | ChEMBL. | 19926281 |
Inhibition (binding) | < 5 % | Inhibition of human Scd1 assessed as conversion of [14C]stearate to [14C]oleate at 10 uM pretreated for 30 mins measured after 4 hrs | ChEMBL. | 19926281 |
T1/2 (ADMET) | = 0.6 hr | Half life in C57BL/6 mouse at 5 mg/kg, iv | ChEMBL. | 19926281 |
T1/2 (ADMET) | = 0.8 hr | Half life in C57BL/6 mouse at 20 mg/kg, po | ChEMBL. | 19926281 |
Vd (ADMET) | = 0.9 L/Kg | Volume of distribution in C57BL/6 mouse at 5 mg/kg, iv | ChEMBL. | 19926281 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.