Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0431 | 0.1043 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.4128 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.1087 | 0.2632 |
Echinococcus multilocularis | geminin | 0.0172 | 0.4128 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0069 | 0.1087 | 0.1087 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0101 | 0.2023 | 0.2023 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.3249 | 0.7872 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0431 | 0.0431 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0431 | 0.1043 |
Onchocerca volvulus | TPPP family protein homolog | 0.0372 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0101 | 0.2023 | 0.2023 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0431 | 0.1043 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0431 | 0.0431 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0431 | 0.1043 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.8095 | 0.8095 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0431 | 0.1043 |
Brugia malayi | hypothetical protein | 0.0307 | 0.8095 | 0.8095 |
Echinococcus granulosus | geminin | 0.0172 | 0.4128 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.4128 | 1 |
Loa Loa (eye worm) | p25-alpha family protein | 0.0372 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0431 | 0.1043 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0142 | 0.3249 | 0.7872 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0101 | 0.2023 | 0.2023 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0431 | 0.1043 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 0.3249 | 0.7872 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.2023 | 0.2023 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1087 | 0.1087 |
Schistosoma mansoni | lipoxygenase | 0.01 | 0.199 | 0.482 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.