Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Diphthamide biosynthesis protein 7 homolog | 0.2261 | 0 | 0.5 |
Echinococcus multilocularis | Cyclin dependent kinase 2 associated protein | 0.2261 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.8657 | 1 | 1 |
Echinococcus granulosus | Cyclin dependent kinase 2 associated protein | 0.2261 | 0 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.8657 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.09 ug ml-1 | In vitro minimum inhibitory concentration against Staphylococcus aureus CDC1. | ChEMBL. | No reference |
MIC (functional) | = 0.39 ug ml-1 | In vitro minimum inhibitory concentration against Staphylococcus aureus SN 7. | ChEMBL. | No reference |
MIC (functional) | = 25 ug ml-1 | In vitro minimum inhibitory concentration against Staphylococcus aureus COL. | ChEMBL. | No reference |
MIC (functional) | = 50 ug ml-1 | In vitro minimum inhibitory concentration against Staphylococcus aureus SN 43. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.