Detailed view for OVOC7528

Basic information

TDR Targets ID: 991191
Onchocerca volvulus, Diphthamide biosynthesis protein 7 homolog
Source Database / ID:  Wormbase Parasite  

pI: 6.4853 | Length (AA): 353 | MW (Da): 39011 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF09806  

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
84 132 2m1l (A) 65 112 65.00 0.000000017 0.74 0.873253 -0.62
284 422 6e1y (A) 98 236 27.00 0.053 1 0.656556 -0.4
288 386 4j87 (A) 227 325 28.00 0.095 0.77 0.512533 -0.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129020)

Species Accession Gene Product
Arabidopsis thaliana AT5G63010   WD40 domain-containing protein
Babesia bovis BBOV_II007280   hypothetical protein
Brugia malayi Bm1_23925   WD domain protein
Candida albicans CaO19.9737   similar to S. cerevisiae YBR246W
Candida albicans CaO19.2191   similar to S. cerevisiae YBR246W
Cryptosporidium parvum cgd6_5020   protein with WD40 repeats
Dictyostelium discoideum DDB_G0270178   WD40 repeat-containing protein
Drosophila melanogaster Dmel_CG3184   CG3184 gene product from transcript CG3184-RA
Echinococcus granulosus EgrG_001034600   WD40 repeat containing protein
Entamoeba histolytica EHI_060980   WD domain containing protein
Echinococcus multilocularis EmuJ_001034600   WD40 repeat containing protein
Homo sapiens ENSG00000148399   diphthamide biosynthesis 7
Loa Loa (eye worm) LOAG_04022   hypothetical protein
Mus musculus 67228   diphthamine biosynethesis 7
Neospora caninum NCLIV_017640   WD domain, G-beta repeat-containing protein, putative
Oryza sativa 4336350   Os04g0507900
Onchocerca volvulus OVOC7528   Diphthamide biosynthesis protein 7 homolog
Plasmodium berghei PBANKA_0106600   diphthine methyltransferase, putative
Plasmodium falciparum PF3D7_0608000   diphthine methyltransferase, putative
Plasmodium knowlesi PKNH_1142300   diphthine methyltransferase, putative
Plasmodium vivax PVX_113565   WD domain, G-beta repeat domain containing protein
Saccharomyces cerevisiae YBR246W   diphthamide synthase
Schistosoma japonicum Sjp_0202050   similar to Uncharacterized protein YBR246W, putative
Schistosoma mansoni Smp_124490   retinoblastoma-binding protein-related
Schmidtea mediterranea mk4.007734.00   Retinoblastoma-binding protein-related
Theileria parva TP02_0184   hypothetical protein

Essentiality

OVOC7528 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0106600 Plasmodium berghei Slow plasmo
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.3056 0.3038 1
0.2374 0.3032 1
0.0657 0.2971 1
0.3052 0.2992 1
0.0657 0.303 1
0.2194 0.3038 1
0.2106 0.3036 1
0.3052 0.2992 1
0.3054 0.3042 1
0.303 0.3026 1
0.3306 0.3046 1
0.1734 0.3045 1
0.3052 0.2992 1
0.1734 0.3045 1
0.0175 0.2721 1
0.3058 0.2978 0.5
0.0188 0.2787 0.5
0.2451 0.2572 1
0.2633 0.3046 1
0.2106 0.3036 1
0.2905 0.3042 1
0.0336 0.2873 1
0.2957 0.3044 1
0.0188 0.2877 0.6373
0.2796 0.3049 1
0.2957 0.3044 1
0.2982 0.304 1
0.0188 0.2787 0.5
0.2294 0.3042 1
0.2982 0.304 1
0.1978 0.3048 1
0.2763 0.2775 1
0.2374 0.3032 1
0.1567 0.3018 1
0.2982 0.304 1
0.0188 0.2877 0.6373
0.2249 0.2602 0.5
0.2969 0.2974 1
0.1734 0.3045 1
0.2982 0.304 1
0.2419 0.2603 0.5
0.2977 0.3017 0.5
0.2969 0.3023 1
0.2879 0.303 1
0.3135 0.3041 1
0.0348 0.2877 1
0.2855 0.3025 0.5
0.0188 0.3025 1
0.3052 0.2992 1
0.3026 0.3043 1
0.1567 0.3018 1
0.2982 0.304 1
0.2249 0.2602 0.5
0.2964 0.3044 1
0.2855 0.3025 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC7528 (Onchocerca volvulus), Diphthamide biosynthesis protein 7 homolog
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