Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.1101 | 1 | 1 | |
Brugia malayi | Protein kinase domain containing protein | 0.0479 | 0.3172 | 0.2469 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0278 | 0.0959 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0479 | 0.3172 | 0.2469 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0276 | 0.0934 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0463 | 0.2989 | 0.2245 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.0959 | 0.0028 |
Echinococcus granulosus | Mastin | 0.0463 | 0.2989 | 0.9171 |
Leishmania major | hypothetical protein, conserved | 0.0479 | 0.3172 | 0.5 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0463 | 0.2989 | 0.9171 |
Toxoplasma gondii | kringle domain-containing protein | 0.0479 | 0.3172 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0276 | 0.0934 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.0959 | 0.0028 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0479 | 0.3172 | 0.3712 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0276 | 0.0934 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0479 | 0.3172 | 0.2469 |
Brugia malayi | Fibulin-1 precursor | 0.0278 | 0.0959 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.1101 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0276 | 0.0934 | 1 |
Onchocerca volvulus | 0.0479 | 0.3172 | 0.2448 | |
Schistosoma mansoni | hypothetical protein | 0.0479 | 0.3172 | 0.2448 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1101 | 1 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0479 | 0.3172 | 0.2469 |
Echinococcus multilocularis | Mastin | 0.0463 | 0.2989 | 0.3404 |
Loa Loa (eye worm) | hypothetical protein | 0.1101 | 1 | 1 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0278 | 0.0959 | 0.0028 |
Echinococcus multilocularis | enteropeptidase | 0.0463 | 0.2989 | 0.3404 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0278 | 0.0959 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.0959 | 0.0028 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0463 | 0.2989 | 0.3404 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0821 | 0.6921 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0276 | 0.0934 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0276 | 0.0934 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.0959 | 0.0028 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0479 | 0.3172 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0479 | 0.3172 | 0.5 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0278 | 0.0959 | 0.0028 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0479 | 0.3172 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0479 | 0.3172 | 0.5 |
Echinococcus granulosus | enteropeptidase | 0.0463 | 0.2989 | 0.9171 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.0959 | 0.0028 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0278 | 0.0959 | 0.0028 |
Onchocerca volvulus | 0.0919 | 0.8 | 0.7788 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1101 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 4.7 % | Evaluated for the inhibition of Hexokinase, type I -catalyzed reactions at 0.3 mM concentration | ChEMBL. | 7108896 |
Inhibition (binding) | = 6.5 % | Evaluated for the inhibition of Hexokinase type III catalyzed reactions at 0.3 mM concentration | ChEMBL. | 7108896 |
Inhibition (binding) | = 8 % | Evaluated for the inhibition of Hexokinase, type I -catalyzed reactions at 0.6 mM concentration | ChEMBL. | 7108896 |
Inhibition (binding) | = 8.7 % | Evaluated for the inhibition of Hexokinase type III catalyzed reactionsat 0.6 mM concentration | ChEMBL. | 7108896 |
Inhibition (binding) | = 28 % | Evaluated for the inhibition of Hexokinase, type II catalyzed reactions at 0.3 mM concentration | ChEMBL. | 7108896 |
Inhibition (binding) | = 30 % | Evaluated for the inhibition of Hexokinase, type II catalyzed reactions at 0.6 mM concentration | ChEMBL. | 7108896 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.