Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | abhydrolase domain containing 6 | Starlite/ChEMBL | References |
Mus musculus | monoglyceride lipase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | monoglyceride lipase | 258 aa | 241 aa | 22.0 % |
Plasmodium falciparum | epoxide hydrolase 2 | abhydrolase domain containing 6 | 336 aa | 295 aa | 19.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.0743 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0316 | 0.5908 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.0743 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0166 | 0.2574 | 0.1858 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.1649 | 0.5 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.009 | 0.088 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.0743 | 0.5 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0084 | 0.0743 | 0.1152 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0084 | 0.0743 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0051 | 0 | 0.5 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.0499 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.1649 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0316 | 0.5908 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.0743 | 0.5 |
Plasmodium falciparum | esterase, putative | 0.0084 | 0.0743 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.0743 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.0743 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0149 | 0.2198 | 0.2816 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.0743 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0316 | 0.5908 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0316 | 0.5908 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0166 | 0.2574 | 0.1978 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0.0743 | 0.5 |
Plasmodium vivax | PST-A protein | 0.0084 | 0.0743 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.1649 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0149 | 0.2198 | 0.3643 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0149 | 0.2198 | 0.2816 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.0743 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.0743 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.0743 | 0.5 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0.0743 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1300 nM | Inhibition of MAGL in mouse brain membrane | ChEMBL. | 20099888 |
IC50 (binding) | = 6960 nM | Inhibition of ABHD6 in mouse brain membrane | ChEMBL. | 20099888 |
IC50 (binding) | > 50 uM | Inhibition of FAAH in mouse brain membrane | ChEMBL. | 20099888 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.