Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | alanyl (membrane) aminopeptidase | Starlite/ChEMBL | References |
Homo sapiens | leucyl/cystinyl aminopeptidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Onchocerca volvulus | Get druggable targets OG5_127217 | All targets in OG5_127217 | |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus granulosus | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Schistosoma japonicum | ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Brugia malayi | Peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus multilocularis | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | puromycin sensitive aminopeptidase | alanyl (membrane) aminopeptidase | 967 aa | 976 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0185 | 1 | 0.5 | |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0131 | 0.3516 | 0.5422 |
Echinococcus multilocularis | aminopeptidase N | 0.0185 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6484 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.0185 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of catalytic activity of human IRAP transfected in HEK293 cells assessed as formation of p-nitroaniline | ChEMBL. | 19757839 | |
Activity (binding) | Displacement of [3H]valsartan from human recombinant AT1 receptor expressed in CHO cells at 10 uM after 40 mins by liquid scintillation counting | ChEMBL. | 19757839 | |
Activity (binding) | Inhibition of catalytic activity of human aminopeptidase N transfected in HEK293 cells assessed as formation of p-nitroaniline | ChEMBL. | 19757839 | |
Ki (binding) | = 5.69 | Inhibition of catalytic activity of human IRAP transfected in HEK293 cells assessed as formation of p-nitroaniline | ChEMBL. | 19757839 |
Ki (binding) | = 7.3 | Inhibition of catalytic activity of human aminopeptidase N transfected in HEK293 cells assessed as formation of p-nitroaniline | ChEMBL. | 19757839 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.