Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Muscarinic acetylcholine receptor M3 | Starlite/ChEMBL | References |
Rattus norvegicus | Muscarinic acetylcholine receptor M1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133264 | All targets in OG5_133264 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133264 | All targets in OG5_133264 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Glycoprotein hormone beta 5 homolog | Muscarinic acetylcholine receptor M3 | 589 aa | 507 aa | 33.7 % |
Schistosoma mansoni | amine GPCR | Muscarinic acetylcholine receptor M1 | 460 aa | 463 aa | 27.0 % |
Loa Loa (eye worm) | hypothetical protein | Muscarinic acetylcholine receptor M1 | 460 aa | 425 aa | 22.1 % |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | Muscarinic acetylcholine receptor M3 | 589 aa | 506 aa | 27.5 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Muscarinic acetylcholine receptor M1 | 460 aa | 432 aa | 26.6 % |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | Muscarinic acetylcholine receptor M3 | 589 aa | 501 aa | 24.8 % |
Echinococcus multilocularis | serotonin receptor | Muscarinic acetylcholine receptor M1 | 460 aa | 432 aa | 26.6 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Muscarinic acetylcholine receptor M1 | 460 aa | 462 aa | 23.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | laminin | 0.0123 | 0.059 | 0.0777 |
Toxoplasma gondii | kringle domain-containing protein | 0.0295 | 0.4363 | 1 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0123 | 0.059 | 0.0327 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0295 | 0.4363 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.059 | 0.0327 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0295 | 0.4363 | 1 |
Echinococcus multilocularis | laminin | 0.0123 | 0.059 | 0.0777 |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.9301 | 0.9281 |
Onchocerca volvulus | 0.0295 | 0.4363 | 0.4206 | |
Schistosoma mansoni | egf-like domain protein | 0.0123 | 0.059 | 0.0327 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0295 | 0.4363 | 1 |
Onchocerca volvulus | Arrow homolog | 0.0123 | 0.059 | 0.0327 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0295 | 0.4363 | 0.5 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0123 | 0.059 | 0.0327 |
Echinococcus granulosus | Tolloid protein 1 | 0.0123 | 0.059 | 0.0777 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0553 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.9301 | 0.9281 |
Onchocerca volvulus | 0.0445 | 0.763 | 0.7563 | |
Loa Loa (eye worm) | hypothetical protein | 0.0553 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.4363 | 0.4206 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0295 | 0.4363 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0295 | 0.4363 | 0.4206 |
Mycobacterium ulcerans | hypothetical protein | 0.0108 | 0.0272 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.059 | 0.0327 |
Schistosoma mansoni | hypothetical protein | 0.0295 | 0.4363 | 0.4206 |
Onchocerca volvulus | 0.0553 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.059 | 0.0327 |
Brugia malayi | Kringle domain containing protein | 0.0295 | 0.4363 | 0.4206 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0123 | 0.059 | 0.0327 |
Brugia malayi | Protein kinase domain containing protein | 0.0295 | 0.4363 | 0.4206 |
Echinococcus multilocularis | fibrillin 1 | 0.0123 | 0.059 | 0.0777 |
Brugia malayi | Fibulin-1 precursor | 0.0123 | 0.059 | 0.0327 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0553 | 1 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0123 | 0.059 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.059 | 0.0327 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.0096 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.059 | 0.0327 |
Leishmania major | hypothetical protein, conserved | 0.0295 | 0.4363 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0553 | 1 | 1 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0123 | 0.059 | 0.0327 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0123 | 0.059 | 0.0327 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0123 | 0.059 | 0.0777 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | uM | Inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M4 of rat heart NG108-15 cells | ChEMBL. | 2066986 |
Ki (binding) | uM | Compound was tested for the inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane; ND denotes not determined | ChEMBL. | 2066986 |
Ki (binding) | 0 uM | Compound was tested for the inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane; ND denotes not determined | ChEMBL. | 2066986 |
Ki (binding) | 0 uM | Inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M4 of rat heart NG108-15 cells | ChEMBL. | 2066986 |
Ki (binding) | = 4.4 uM | Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells. | ChEMBL. | 2066986 |
Ki (binding) | = 4.4 uM | Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells. | ChEMBL. | 2066986 |
Ki (binding) | = 4.4 uM | Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells. | ChEMBL. | 2066986 |
Ki (binding) | = 4.4 uM | Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells. | ChEMBL. | 2066986 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.