Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinesin family member 11 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0472 | 0.0472 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0032 | 0.06 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0472 | 0.7866 |
Entamoeba histolytica | kinesin, putative | 0.0032 | 0.06 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0204 | 0.8089 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.8597 | 1 |
Schistosoma mansoni | kinesin eg-5 | 0.0032 | 0.06 | 0.0698 |
Onchocerca volvulus | 0.0232 | 0.9317 | 1 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0472 | 0.0549 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0472 | 0.7866 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0232 | 0.9317 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0472 | 0.0549 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.0247 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0472 | 0.0549 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0032 | 0.06 | 0.0742 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0472 | 0.0549 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0204 | 0.8089 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0472 | 0.0583 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0032 | 0.06 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0472 | 0.0472 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0 | 0.5 |
Plasmodium vivax | kinesin-5 | 0.0032 | 0.06 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0 | 0.5 |
Brugia malayi | Kinesin motor domain containing protein | 0.0032 | 0.06 | 0.0742 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0425 | 0.0425 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0472 | 0.0583 |
Plasmodium falciparum | kinesin-5 | 0.0032 | 0.06 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0472 | 0.0472 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.31 uM | Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay | ChEMBL. | 21899292 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.