Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | phosphatidylinositol 5 phosphate 4 kinase type 2 | 0.0163 | 0.0986 | 0.0986 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.1983 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0343 | 0.2316 | 0.2316 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.1983 | 1 |
Schistosoma mansoni | phosphatidylinositol-4-phosphate 5-kinase type II | 0.0163 | 0.0986 | 0.0986 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC | 0.0578 | 0.4052 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0298 | 0.1983 | 0.5 |
Schistosoma mansoni | ets-related | 0.0221 | 0.1412 | 0.1412 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0238 | 0.1687 |
Schistosoma mansoni | gabp alpha | 0.0073 | 0.0316 | 0.0316 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.1983 | 1 |
Schistosoma mansoni | phosphatidylinositol-4-phosphate 5-kinase type II | 0.0163 | 0.0986 | 0.0986 |
Onchocerca volvulus | 0.0238 | 0.1538 | 1 | |
Plasmodium falciparum | nicotinamide/nicotinic acid mononucleotide adenylyltransferase | 0.0578 | 0.4052 | 0.5 |
Brugia malayi | Ets-domain containing protein | 0.0073 | 0.0316 | 0.224 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1383 | 1 | 1 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0073 | 0.0316 | 0.224 |
Brugia malayi | Pip kinase protein 2 | 0.0163 | 0.0986 | 0.6984 |
Plasmodium vivax | nicotinate-nucleotide adenylyltransferase, putative | 0.0578 | 0.4052 | 1 |
Treponema pallidum | hypothetical protein | 0.0578 | 0.4052 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1383 | 1 | 1 |
Mycobacterium tuberculosis | Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic | 0.0578 | 0.4052 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0209 | 0.1325 | 0.9382 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0073 | 0.0316 | 0.0316 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0298 | 0.1983 | 0.5 |
Echinococcus granulosus | geminin | 0.0343 | 0.2316 | 0.2316 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.1983 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.1983 | 1 |
Brugia malayi | Fli-1 protein | 0.0221 | 0.1412 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.1983 | 1 |
Mycobacterium ulcerans | bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein | 0.0578 | 0.4052 | 1 |
Loa Loa (eye worm) | fli-1 protein | 0.0221 | 0.1412 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0298 | 0.1983 | 0.5 |
Echinococcus multilocularis | phosphatidylinositol 5 phosphate 4 kinase type 2 | 0.0163 | 0.0986 | 0.0986 |
Loa Loa (eye worm) | pip kinase 2 | 0.0163 | 0.0986 | 0.6984 |
Echinococcus multilocularis | geminin | 0.0343 | 0.2316 | 0.2316 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.0986 | 0.6984 |
Onchocerca volvulus | 0.0163 | 0.0986 | 0.641 | |
Brugia malayi | Ets-domain containing protein | 0.0073 | 0.0316 | 0.224 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.1983 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.1983 | 1 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0073 | 0.0316 | 0.0316 |
Schistosoma mansoni | hypothetical protein | 0.0343 | 0.2316 | 0.2316 |
Brugia malayi | Pre-SET motif family protein | 0.0209 | 0.1325 | 0.9382 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.