Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.2529 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0038 | 0.2574 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0038 | 0.2574 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0095 | 0.7738 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0095 | 0.7738 | 1 |
Leishmania major | trypanothione reductase | 0.0037 | 0.2529 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0013 | 0.0312 | 0.0958 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.2529 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0013 | 0.0312 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0072 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0085 | 0.6874 | 0.8837 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0072 | 0.0286 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0072 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0013 | 0.0312 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0072 | 0.0286 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0085 | 0.6874 | 0.8837 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0072 | 0.0286 |
Onchocerca volvulus | 0.001 | 0.0072 | 0.5 | |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.2529 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0072 | 0.0286 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0013 | 0.0312 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0072 | 0.0286 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.2529 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.2529 | 1 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0072 | 0.0286 |
Trypanosoma brucei | trypanothione reductase | 0.0037 | 0.2529 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0072 | 0.0286 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0.0312 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0072 | 0.0286 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0072 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0037 | 0.2529 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0085 | 0.6874 | 0.8837 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0013 | 0.0312 | 0.0958 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0072 | 0.0286 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0013 | 0.0312 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0095 | 0.7738 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.2529 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0072 | 0.0286 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0072 | 0.0286 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0072 | 0.0286 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0085 | 0.6874 | 0.8837 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0095 | 0.7738 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0037 | 0.2529 | 0.2985 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0072 | 0.0286 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0013 | 0.0312 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0013 | 0.0312 | 0.1234 |
Brugia malayi | glutathione reductase | 0.0037 | 0.2529 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.2529 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0072 | 0.0286 |
Mycobacterium tuberculosis | Probable reductase | 0.0085 | 0.6874 | 0.8837 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0072 | 0.0286 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0072 | 0.0286 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0013 | 0.0312 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0072 | 0.0286 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0072 | 0.0286 |
Treponema pallidum | NADH oxidase | 0.0013 | 0.0312 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.2529 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0.0312 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0085 | 0.6874 | 0.8837 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0072 | 0.0286 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0072 | 0.0286 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0013 | 0.0312 | 0.0242 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0013 | 0.0312 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 20 mm | Antibacterial activity against Escherichia coli at 2 mg/ml by agar diffusion method | ChEMBL. | 19581025 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Escherichia coli by twofold serial broth dilution method | ChEMBL. | 19581025 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.