Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0166 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2207 | 0.2207 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.1789 | 1 |
Echinococcus granulosus | lamin | 0.0057 | 0.2996 | 0.2996 |
Brugia malayi | Inositol-1 | 0.0038 | 0.1789 | 0.5971 |
Echinococcus granulosus | lamin dm0 | 0.0057 | 0.2996 | 0.2996 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.1789 | 0.1789 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.07 | 0.07 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2207 | 0.2207 |
Echinococcus multilocularis | musashi | 0.0057 | 0.2996 | 0.2996 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.1531 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1789 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.07 | 0.07 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0057 | 0.2996 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.1789 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0057 | 0.2996 | 0.2996 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.2207 | 0.7369 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.07 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0031 | 0.1292 | 0.4313 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.07 | 0.2338 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0057 | 0.2996 | 1 |
Brugia malayi | intermediate filament protein | 0.0057 | 0.2996 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1789 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.1789 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.07 | 0.07 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.1789 | 0.1789 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0028 | 0.1097 | 0.1097 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2207 | 0.2207 |
Loa Loa (eye worm) | intermediate filament protein | 0.0057 | 0.2996 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 0.1789 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.07 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2207 | 0.2207 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.1789 | 0.1789 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.2207 | 0.7369 |
Echinococcus granulosus | intermediate filament protein | 0.0057 | 0.2996 | 0.2996 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2207 | 0.2207 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1789 | 1 |
Echinococcus multilocularis | geminin | 0.0166 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0057 | 0.2996 | 0.2996 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.1789 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0057 | 0.2996 | 0.2996 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2207 | 0.2207 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.07 | 0.07 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.07 | 0.5 |
Onchocerca volvulus | 0.0057 | 0.2996 | 1 | |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0034 | 0.1531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1097 | 0.3662 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.1789 | 0.1789 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0028 | 0.1097 | 0.1097 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.1789 | 0.5971 |
Onchocerca volvulus | 0.0057 | 0.2996 | 1 | |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.07 | 0.5 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0038 | 0.1789 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.2928 | 0.9776 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.2996 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2207 | 0.2207 |
Schistosoma mansoni | lamin | 0.0057 | 0.2996 | 0.2996 |
Schistosoma mansoni | lamin | 0.0057 | 0.2996 | 0.2996 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.103 | 0.3438 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0031 | 0.1292 | 0.4313 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.103 | 0.3438 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.07 | 0.2338 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1789 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.1789 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
K0.5 (binding) | = 3950 nM | The compound is evaluated for the affinity towards Dopamine receptor D1, using [3H]- SCH 23390 as ligand on rat striatal membranes. | ChEMBL. | 9216832 |
K0.5 (binding) | = 3950 nM | The compound is evaluated for the affinity towards Dopamine receptor D1, using [3H]- SCH 23390 as ligand on rat striatal membranes. | ChEMBL. | 9216832 |
K0.5 (binding) | > 10000 nM | The compound is evaluated for the affinity towards Dopamine receptor D2, using [3H]-spiperone as ligand on rat striatal membranes. | ChEMBL. | 9216832 |
K0.5 (binding) | > 10000 nM | The compound is evaluated for the affinity towards Dopamine receptor D2, using [3H]-spiperone as ligand on rat striatal membranes. | ChEMBL. | 9216832 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.