Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | squalene monooxygenase, putative | 0.0242 | 0.5 | 0.5 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0242 | 0.5 | 0.5 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0242 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 26 mg kg-1 | Anticonvulsant activity in mice using the maximal electroshock seizure test. | ChEMBL. | 8035421 |
ED50 (functional) | = 26 mg kg-1 | Anticonvulsant activity in mice using the maximal electroshock seizure test. | ChEMBL. | 8035421 |
Locomotor activity (functional) | = 47 mg kg-1 | Locomotor activity in maximal electroshock seizure+ indicates increase at 100 mg/kg | ChEMBL. | 8035421 |
Locomotor activity (functional) | = 47 mg kg-1 | Locomotor activity in maximal electroshock seizure+ indicates increase at 100 mg/kg | ChEMBL. | 8035421 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.