Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0832 | 0.9606 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0063 | 0.3296 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0063 | 0.3296 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0063 | 0.3296 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0063 | 0.3296 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0063 | 0.3296 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0161 | 1 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0063 | 0.3296 | 0.3296 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0161 | 1 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0866 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0161 | 1 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0161 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0161 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0161 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0063 | 0.3296 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0063 | 0.3296 | 1 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0866 | 0.0866 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0063 | 0.3296 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0161 | 1 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0161 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0063 | 0.3296 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0161 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 0.0866 | 0.5 | |
Leishmania major | dihydroorotate dehydrogenase | 0.0161 | 1 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0866 | 0.0866 |
Onchocerca volvulus | 0.0027 | 0.0866 | 0.5 | |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0063 | 0.3296 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0866 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0161 | 1 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0161 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0161 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0866 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0161 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0063 | 0.3296 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 29.48 % | Inhibition of T-type calcium channel alpha1G expressed in human HEK293 cells assessed as inhibition of KCl-induced decrease in calcium level at 10 uM after 60 mins by FDSS6000 assay | ChEMBL. | 20382529 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.