Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase-activated protein kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Brugia malayi | map kinase activated protein kinase protein 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Schistosoma japonicum | ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase-activated protein kinase 2 | 370 aa | 303 aa | 26.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0052 | 0.0341 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.0341 | 0.0341 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0052 | 0.0341 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0052 | 0.0341 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0341 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0052 | 0.0341 | 0.0341 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0052 | 0.0341 | 0.0341 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0052 | 0.0341 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0052 | 0.0341 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0052 | 0.0341 | 0.0341 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0052 | 0.0341 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0341 | 0.5 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | 0.0218 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0052 | 0.0341 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0052 | 0.0341 | 0.0341 |
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | 0.0218 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0052 | 0.0341 | 0.0341 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | 0.0218 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0052 | 0.0341 | 0.5 |
Brugia malayi | MAP kinase sur-1 | 0.0052 | 0.0341 | 0.0341 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0341 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0052 | 0.0341 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0218 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0052 | 0.0341 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0341 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.5 uM | Inhibition of MK2 assessed as inhibition of [33P]ATP incorporation in to substrate after 30 mins by scintillation counting | ChEMBL. | 20643547 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.