Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.0563 | 0.1274 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.0563 | 1 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.0563 | 0.0563 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0496 | 1 | 1 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0496 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.0563 | 0.0563 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.0763 | 0.0763 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0073 | 0.0763 | 0.0763 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0073 | 0.0763 | 0.0763 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0073 | 0.0763 | 0.0763 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0496 | 1 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0042 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0496 | 1 | 1 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0496 | 1 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0042 | 0.0096 | 0.0096 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0073 | 0.0763 | 0.0763 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0073 | 0.0763 | 0.0763 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0 | 0.5 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0496 | 1 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.0563 | 0.0563 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0496 | 1 | 1 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0496 | 1 | 1 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0496 | 1 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.0563 | 0.0563 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0496 | 1 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0496 | 1 | 1 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0496 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.0763 | 0.0763 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0073 | 0.0763 | 0.0763 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.0563 | 1 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0496 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.0563 | 1 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0496 | 1 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.0763 | 0.0763 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0241 | 0.4423 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.0563 | 0.0563 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.0563 | 0.0563 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0496 | 1 | 1 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0496 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 20 uM | Inhibitory activity towards tyrosine phosphorylation for the epidermal growth factor-receptor kinase | ChEMBL. | 12127526 |
IC50 (binding) | > 20 uM | Inhibitory activity towards tyrosine phosphorylation in cells expressing PDGF-receptor beta kinase | ChEMBL. | 12127526 |
IC50 (binding) | > 20 uM | Inhibition of tyrosine phosphorylation in cells expressing human VEGFR2 (Flk-1/KDR) kinase | ChEMBL. | 12127526 |
IC50 (binding) | > 20 uM | Inhibitory activity towards tyrosine phosphorylation for the epidermal growth factor-receptor kinase | ChEMBL. | 12127526 |
IC50 (binding) | > 20 uM | Inhibitory activity towards tyrosine phosphorylation in cells expressing PDGF-receptor beta kinase | ChEMBL. | 12127526 |
IC50 (binding) | > 20 uM | Inhibition of tyrosine phosphorylation in cells expressing human VEGFR2 (Flk-1/KDR) kinase | ChEMBL. | 12127526 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.