Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0071 | 0.297 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0071 | 0.297 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0071 | 0.297 | 1 |
Loa Loa (eye worm) | cyclophilin Ovcyp-2 | 0.0071 | 0.297 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.1627 | 0.5478 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1627 | 0.0413 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0437 | 0.1473 |
Trypanosoma brucei | cyclophilin, putative | 0.0071 | 0.297 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1627 | 0.0413 |
Schistosoma mansoni | cyclophilin | 0.0071 | 0.297 | 0.1951 |
Toxoplasma gondii | cyclophilin precursor | 0.0071 | 0.297 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0039 | 0.1267 | 0.5 |
Plasmodium vivax | cyclophilin, putative | 0.0071 | 0.297 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1627 | 0.0413 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1627 | 0.0413 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0039 | 0.1267 | 0.3273 |
Toxoplasma gondii | cyclophilin 1, putative | 0.0071 | 0.297 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0039 | 0.1267 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0039 | 0.1267 | 0.3273 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1627 | 0.0413 |
Leishmania major | cyclophilin a | 0.0071 | 0.297 | 1 |
Trichomonas vaginalis | peptidyl-prolyl cis-trans isomerase A, ppia, putative | 0.0071 | 0.297 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.1267 | 0.3273 |
Echinococcus multilocularis | expressed protein | 0.0071 | 0.297 | 0.1951 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0039 | 0.1267 | 0.3273 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0039 | 0.1267 | 0.5 |
Brugia malayi | cyclophilin-type peptidyl-prolyl cis-trans isomerase-2, Bmcyp-2 | 0.0071 | 0.297 | 1 |
Trypanosoma cruzi | cyclophilin, putative | 0.0071 | 0.297 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0039 | 0.1267 | 0.5 |
Onchocerca volvulus | 0.0071 | 0.297 | 0.5 | |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.1267 | 0.3273 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0039 | 0.1267 | 0.5 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase | 0.0071 | 0.297 | 1 |
Loa Loa (eye worm) | cyclophilin-type peptidyl-prolyl cis-trans isomerase-2 | 0.0071 | 0.297 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0039 | 0.1267 | 0.3273 |
Echinococcus granulosus | expressed protein | 0.0071 | 0.297 | 0.1951 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0039 | 0.1267 | 0.5 |
Trypanosoma cruzi | 21 kDa cyclophilin, putative | 0.0071 | 0.297 | 1 |
Leishmania major | cyclophilin 11, putative | 0.0071 | 0.297 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1627 | 0.0413 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0039 | 0.1267 | 0.4264 |
Trypanosoma brucei | cyclophilin a | 0.0071 | 0.297 | 1 |
Trypanosoma cruzi | cyclophilin type peptidyl-prolyl cis-trans isomerase | 0.0071 | 0.297 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0039 | 0.1267 | 0.3273 |
Brugia malayi | cyclophilin-type peptidyl-prolyl cis-trans isomerase-3, Bmcyp-3 | 0.0071 | 0.297 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0039 | 0.1267 | 0.3273 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.1627 | 0.4697 |
Leishmania major | cyclophilin 4, putative | 0.0071 | 0.297 | 1 |
Plasmodium vivax | unspecified product | 0.0071 | 0.297 | 1 |
Trypanosoma cruzi | rotamase, putative | 0.0071 | 0.297 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1627 | 0.0413 |
Onchocerca volvulus | 0.0071 | 0.297 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.4611 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.