Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.0011 | 0.0017 | 0.5 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0018 | 0.0563 | 0.1352 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.4059 | 0.4049 |
Schistosoma mansoni | peroxidasin | 0.0066 | 0.4059 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0011 | 0.0017 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0066 | 0.4059 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.4059 | 0.4049 |
Trichomonas vaginalis | AGC family protein kinase | 0.0011 | 0.0017 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0066 | 0.4059 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.4059 | 0.4049 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0018 | 0.0563 | 0.1352 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.4059 | 0.4049 |
Echinococcus granulosus | protein kinase c iota type | 0.0018 | 0.0563 | 0.1352 |
Trichomonas vaginalis | AGC family protein kinase | 0.0011 | 0.0017 | 1 |
Schistosoma mansoni | peroxidasin | 0.0066 | 0.4059 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0018 | 0.0563 | 0.1352 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.9227 | 0.9226 |
Echinococcus granulosus | peroxidasin | 0.0066 | 0.4059 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0066 | 0.4059 | 0.4049 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.9227 | 0.9226 |
Trichomonas vaginalis | AGC family protein kinase | 0.0011 | 0.0017 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0018 | 0.0563 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.9227 | 0.9226 |
Brugia malayi | Animal haem peroxidase family protein | 0.0066 | 0.4059 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0066 | 0.4059 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0018 | 0.0563 | 0.1352 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.4059 | 0.4049 |
Brugia malayi | Peroxidasin | 0.0066 | 0.4059 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0018 | 0.0563 | 0.1352 |
Entamoeba histolytica | protein kinase, putative | 0.0011 | 0.0017 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0011 | 0.0017 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0066 | 0.4059 | 1 |
Brugia malayi | hypothetical protein | 0.0066 | 0.4059 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.9774 | 0.9773 |
Trichomonas vaginalis | AGC family protein kinase | 0.0011 | 0.0017 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.4059 | 0.4049 |
Entamoeba histolytica | protein kinase, putative | 0.0011 | 0.0017 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0018 | 0.0563 | 0.1352 |
Trichomonas vaginalis | AGC family protein kinase | 0.0011 | 0.0017 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0066 | 0.4059 | 0.4049 |
Trichomonas vaginalis | AGC family protein kinase | 0.0011 | 0.0017 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0066 | 0.4059 | 0.4049 |
Entamoeba histolytica | protein kinase, putative | 0.0011 | 0.0017 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0011 | 0.0017 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.4059 | 0.4049 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.4059 | 0.4049 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.4059 | 0.4049 |
Brugia malayi | Animal haem peroxidase family protein | 0.0066 | 0.4059 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.0018 | 0.0563 | 0.1352 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.4059 | 0.4049 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.4059 | 0.4049 |
Trichomonas vaginalis | AGC family protein kinase | 0.0011 | 0.0017 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.4059 | 0.4049 |
Onchocerca volvulus | 0.0136 | 0.9227 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.4059 | 0.4049 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.4059 | 0.4049 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0066 | 0.4059 | 0.4049 |
Toxoplasma gondii | AGC kinase | 0.0011 | 0.0017 | 0.5 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0011 | 0.0017 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0066 | 0.4059 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0018 | 0.0563 | 0.1352 |
Brugia malayi | protein kinase C II. | 0.0018 | 0.0563 | 0.1352 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0066 | 0.4059 | 0.4049 |
Trichomonas vaginalis | AGC family protein kinase | 0.0011 | 0.0017 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0018 | 0.0563 | 0.1352 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.726 uM | Tested in vitro for cytotoxicity of the compound in SF-268 cell lines | ChEMBL. | 8035426 |
GI50 (functional) | = 0.726 uM | Tested in vitro for cytotoxicity of the compound in SF-268 cell lines | ChEMBL. | 8035426 |
GI50 (functional) | = 1.99 uM | Tested in vitro for cytotoxicity of the compound in MALME-3M | ChEMBL. | 8035426 |
GI50 (functional) | = 1.99 uM | Tested in vitro for cytotoxicity of the compound in MALME-3M | ChEMBL. | 8035426 |
GI50 (functional) | = 2.48 uM | Tested in vitro for cytotoxicity of the compound in COLO 205 cell lines | ChEMBL. | 8035426 |
GI50 (functional) | = 2.48 uM | Tested in vitro for cytotoxicity of the compound in COLO 205 cell lines | ChEMBL. | 8035426 |
GI50 (functional) | = 2.67 uM | Tested in vitro for cytotoxicity of the compound in DMS114 cell lines | ChEMBL. | 8035426 |
GI50 (functional) | = 2.67 uM | Tested in vitro for cytotoxicity of the compound in DMS114 cell lines | ChEMBL. | 8035426 |
GI50 (functional) | = 5.02 uM | Tested in vitro for cytotoxicity of the compound in CCRF-CEM cell lines | ChEMBL. | 8035426 |
GI50 (functional) | = 5.02 uM | Tested in vitro for cytotoxicity of the compound in CCRF-CEM cell lines | ChEMBL. | 8035426 |
GI50 (functional) | = 5.23 uM | Tested in vitro for cytotoxicity of the compound in A549/ATCC cell lines | ChEMBL. | 8035426 |
GI50 (functional) | = 5.23 uM | Tested in vitro for cytotoxicity of the compound in A549/ATCC cell lines | ChEMBL. | 8035426 |
GI50 (functional) | = 18.2 uM | Tested in vitro for cytotoxicity of the compound in IGROV1 cell lines | ChEMBL. | 8035426 |
GI50 (functional) | = 18.2 uM | Tested in vitro for cytotoxicity of the compound in IGROV1 cell lines | ChEMBL. | 8035426 |
GI50 (functional) | = 19.6 uM | Tested in vitro for cytotoxicity of the compound in CAKI-1 cell lines | ChEMBL. | 8035426 |
GI50 (functional) | = 19.6 uM | Tested in vitro for cytotoxicity of the compound in CAKI-1 cell lines | ChEMBL. | 8035426 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.