Detailed information for compound 1138317

Basic information

Technical information
  • TDR Targets ID: 1138317
  • Name: 2,2-difluoroethanamine
  • MW: 81.0646 | Formula: C2H5F2N
  • H donors: 1 H acceptors: 0 LogP: 0.14 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCC(F)F
  • InChi: 1S/C2H5F2N/c3-2(4)1-5/h2H,1,5H2
  • InChiKey: OVRWUZYZECPJOB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,2-difluoroethylamine
  • 430-67-1
  • SBB009831
  • Ethylamine, 2,2-difluoro-
  • CF2HCH2NH2

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi intermediate filament protein 0.0032 0.1093 0.3639
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0917 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.3655 0.3655
Echinococcus granulosus tar DNA binding protein 0.0062 0.3003 0.3003
Brugia malayi hypothetical protein 0.003 0.0917 0.3052
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.3655 0.3655
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.3655 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.2218 0.7383
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0917 0.5
Brugia malayi TAR-binding protein 0.0062 0.3003 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.1054 0.351
Loa Loa (eye worm) hypothetical protein 0.0034 0.1191 0.3966
Loa Loa (eye worm) hypothetical protein 0.003 0.0917 0.3052
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.2218 0.7383
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.1093 0.3639
Echinococcus granulosus intermediate filament protein 0.0032 0.1093 0.1093
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3003 0.3003
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.1191 0.3966
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.3655 0.5
Onchocerca volvulus 0.0032 0.1093 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.1093 0.3639
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0109 0.0363
Echinococcus multilocularis tar DNA binding protein 0.0062 0.3003 0.3003
Schistosoma mansoni intermediate filament proteins 0.0032 0.1093 0.1093
Loa Loa (eye worm) RNA binding protein 0.0062 0.3003 1
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0917 0.5
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.3655 0.5
Echinococcus multilocularis lamin dm0 0.0032 0.1093 0.1093
Echinococcus granulosus lamin 0.0032 0.1093 0.1093
Brugia malayi hypothetical protein 0.0019 0.0228 0.0759
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0917 0.5
Schistosoma mansoni lamin 0.0032 0.1093 0.1093
Echinococcus granulosus lamin dm0 0.0032 0.1093 0.1093
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0109 0.0363
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.3655 0.3655
Echinococcus multilocularis lamin 0.0032 0.1093 0.1093
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0917 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.3003 1
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.3655 0.3655
Loa Loa (eye worm) hypothetical protein 0.005 0.2218 0.7383
Schistosoma mansoni hypothetical protein 0.0034 0.1191 0.1191
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.3655 0.5
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3003 0.3003
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.3655 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.1093 0.3639
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.3655 0.5
Schistosoma mansoni lamin 0.0032 0.1093 0.1093
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3003 0.3003
Loa Loa (eye worm) TAR-binding protein 0.0062 0.3003 1
Loa Loa (eye worm) intermediate filament protein 0.0032 0.1093 0.3639
Echinococcus multilocularis geminin 0.0168 1 1
Echinococcus multilocularis musashi 0.0032 0.1093 0.1093
Brugia malayi RNA binding protein 0.0062 0.3003 1
Schistosoma mansoni hypothetical protein 0.0168 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.3003 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3003 0.3003
Onchocerca volvulus 0.0032 0.1093 0.5
Schistosoma mansoni hypothetical protein 0.0168 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3003 0.3003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.2218 0.7383
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0917 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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