Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0209 | 1 | 1 |
Onchocerca volvulus | 0.0209 | 1 | 1 | |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.2814 | 0.2814 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0209 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0209 | 1 | 1 |
Onchocerca volvulus | 0.0209 | 1 | 1 | |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0209 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 0.2814 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0209 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0067 | 0.2814 | 0.2814 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 0.2814 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0067 | 0.2814 | 0.2814 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 0.2814 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0011 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.2814 | 0.2814 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | 0.0209 | 1 | 1 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0067 | 0.2814 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.2814 | 0.2814 |
Schistosoma mansoni | tyrosinase precursor | 0.0209 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.2814 | 0.2814 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0209 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0067 | 0.2814 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 0.2814 | 1 |
Onchocerca volvulus | 0.0209 | 1 | 1 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0067 | 0.2814 | 0.2814 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | tyrosinase precursor | 0.0209 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0011 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | nM | Functional activity towards human glucocorticoid receptor in genetically engineered cell line containing glucocorticoid response element and reporter gene encoding a secreted form of alkaline phosphatase | ChEMBL. | 15081010 |
IC50 (functional) | 0 nM | Functional activity towards human glucocorticoid receptor in genetically engineered cell line containing glucocorticoid response element and reporter gene encoding a secreted form of alkaline phosphatase | ChEMBL. | 15081010 |
IC50 (binding) | = 570 nM | Binding affinity against human Glucocorticoid receptor (GR) using [3H]-dexamethasone as radioligand | ChEMBL. | 15081010 |
IC50 (binding) | = 570 nM | Binding affinity against human Glucocorticoid receptor (GR) using [3H]-dexamethasone as radioligand | ChEMBL. | 15081010 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.