Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Aminopeptidase N | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus multilocularis | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Onchocerca volvulus | Get druggable targets OG5_127217 | All targets in OG5_127217 | |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus granulosus | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Schistosoma japonicum | ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 975 aa | 29.1 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 988 aa | 28.5 % |
Onchocerca volvulus | Aminopeptidase N | 963 aa | 893 aa | 32.0 % | |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 29.2 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | 0.0062 | 0.2855 | 0.2855 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0042 | 0.1131 | 1 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0116 | 0.7601 | 0.8738 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0042 | 0.1131 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0042 | 0.1131 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.1131 | 0.1131 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0042 | 0.1131 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0.1131 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.2272 | 0.2611 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.2272 | 0.2611 |
Onchocerca volvulus | 0.0143 | 1 | 1 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.074 | 0.074 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0042 | 0.1131 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0042 | 0.1131 | 0.1131 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0042 | 0.1131 | 1 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0042 | 0.1131 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.8699 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.63 | 0.7242 |
Echinococcus granulosus | aminopeptidase N | 0.0143 | 1 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0042 | 0.1131 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0062 | 0.2855 | 0.3282 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.074 | 0.0851 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.2272 | 0.2272 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0.1131 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0042 | 0.1131 | 1 |
Loa Loa (eye worm) | aminopeptidase N | 0.0042 | 0.1131 | 0.13 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.2272 | 0.2272 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0042 | 0.1131 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0042 | 0.1131 | 1 |
Entamoeba histolytica | aminopeptidase, putative | 0.0042 | 0.1131 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.22 mM | Cytotoxicity against human HL60 cells expressing aminopeptidase N after 72 hrs by MTT assay | ChEMBL. | 20637634 |
IC50 (functional) | = 9.48 mM | Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay | ChEMBL. | 20637634 |
IC50 (binding) | = 6.92 uM | Inhibition of pig kidney microsome aminopeptidase N after 30 mins by UV-vis spectrophotometric analysis | ChEMBL. | 20637634 |
IC50 (binding) | = 60.4 uM | Inhibition of MMP2 after 30 mins | ChEMBL. | 20637634 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.