Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1145 | 0.078 | 1 |
Brugia malayi | Trypsin family protein | 0.0237 | 0.0121 | 0.0121 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0237 | 0.0121 | 0.0376 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.1145 | 0.078 | 0.2432 |
Schistosoma mansoni | high-affinity choline transporter | 0.1145 | 0.078 | 0.2432 |
Schistosoma mansoni | inositol transporter | 0.4488 | 0.3207 | 1 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.1145 | 0.078 | 0.2432 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.1145 | 0.078 | 0.2432 |
Schistosoma mansoni | inositol transporter | 0.4488 | 0.3207 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1145 | 0.078 | 1 |
Onchocerca volvulus | 0.0237 | 0.0121 | 0.1546 | |
Echinococcus multilocularis | solute carrier family 5 | 0.4488 | 0.3207 | 1 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.1145 | 0.078 | 0.5 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.4488 | 0.3207 | 1 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.1145 | 0.078 | 0.2432 |
Brugia malayi | GH02984p | 0.1145 | 0.078 | 0.078 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.4488 | 0.3207 | 1 |
Onchocerca volvulus | 0.0213 | 0.0103 | 0.1318 | |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.4488 | 0.3207 | 1 |
Schistosoma mansoni | sodium/solute symporter | 0.1145 | 0.078 | 0.2432 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.4488 | 0.3207 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0121 | 0.1546 |
Onchocerca volvulus | 0.1145 | 0.078 | 1 | |
Echinococcus granulosus | solute carrier family 5 | 0.4488 | 0.3207 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0121 | 0.1546 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.4488 | 0.3207 | 1 |
Brugia malayi | Sodium:solute symporter family protein | 0.1145 | 0.078 | 0.078 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0237 | 0.0121 | 0.0376 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.02 uM | Compound was evaluated in vitro for its ability to inhibit the activity of Trypsin | ChEMBL. | No reference |
IC50 (binding) | = 0.026 uM | Compound was evaluated in vitro for its ability to inhibit the activity of human alpha Thrombin | ChEMBL. | No reference |
IC50 (binding) | = 0.5 uM | Compound was evaluated in vitro for its ability to inhibit the activity of Plasmin | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.