Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0304 | 0.2583 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.1116 | 1 | 0.5 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.1116 | 1 | 1 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | snurportin 1 | 0.0304 | 0.2583 | 1 |
Treponema pallidum | licC protein (licC) | 0.0205 | 0.1677 | 0.5 |
Brugia malayi | Importin beta-1 subunit | 0.0028 | 0.0069 | 0.1253 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0019 | 1 |
Schistosoma mansoni | importin beta-1 | 0.0028 | 0.0069 | 0.0266 |
Echinococcus multilocularis | snurportin 1 | 0.0304 | 0.2583 | 0.3705 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0069 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0205 | 0.1677 | 1 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.1116 | 1 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.0069 | 1 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.0069 | 0.0409 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0019 | 1 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0019 | 1 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0069 | 0.0266 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0028 | 0.0069 | 0.0098 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0785 | 0.6973 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0019 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0069 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0019 | 1 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0069 | 1 |
Echinococcus granulosus | importin subunit beta 1 | 0.0028 | 0.0069 | 0.0266 |
Brugia malayi | RNA, U transporter 1 | 0.0081 | 0.0548 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0304 | 0.2583 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.