Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cpg binding protein | 0.0032 | 0.1619 | 0.146 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.3654 | 0.6132 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.1653 | 0.1495 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1653 | 0.1653 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1653 | 0.1653 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0147 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0147 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.1653 | 0.249 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0147 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.3654 | 0.6132 |
Echinococcus multilocularis | geminin | 0.0178 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0147 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0104 | 0.5774 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0147 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0147 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0147 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0147 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.3654 | 0.3534 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3654 | 0.3654 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1653 | 0.1653 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0147 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0065 | 0.3504 | 0.3504 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.3654 | 0.3534 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0147 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3654 | 0.3654 |
Echinococcus granulosus | cpg binding protein | 0.0032 | 0.1619 | 0.146 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.3867 | 0.6524 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0147 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0147 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0294 | 0.011 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0058 | 0.3103 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.3654 | 0.6137 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3654 | 0.3654 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3654 | 0.3654 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.1518 | 0.1518 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3654 | 0.3654 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.1518 | 0.2243 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3867 | 0.6519 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.1619 | 0.1619 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0186 | 0.0186 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.5774 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.1653 | 0.1495 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0147 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.1619 | 0.1619 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0147 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0147 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.1653 | 0.1495 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0147 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.1653 | 0.1495 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.3867 | 0.3867 |
Brugia malayi | RNA binding protein | 0.0068 | 0.3654 | 0.6137 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0294 | 0.011 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0147 | 0.5 |
Onchocerca volvulus | 0.0031 | 0.1518 | 0.5 | |
Brugia malayi | TAR-binding protein | 0.0068 | 0.3654 | 0.6137 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0104 | 0.5774 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.1653 | 0.249 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1653 | 0.248 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.1653 | 0.1495 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0147 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0104 | 0.5774 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.1653 | 0.1495 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.1653 | 0.248 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.3654 | 0.6132 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1653 | 0.1653 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.1518 | 0.2233 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 15 mm | Antibacterial activity against Escherichia coli ATCC 25922 assessed as zone of inhibition at 100 ug/disc after 24 hrs by agar disc diffusion method | ChEMBL. | 21937152 |
IZ (functional) | = 15 mm | Antifungal activity against Candida albicans ATCC 90028 assessed as zone of inhibition at 100 ug/disc after 48 hrs by agar disc diffusion method | ChEMBL. | 21937152 |
MIC (functional) | = 12.5 ug ml-1 | Antifungal activity against Candida albicans ATCC 90028 after 18 to 24 hrs by NCCLS M7-A5 based agar dilution method | ChEMBL. | 21937152 |
MIC (functional) | = 25 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 to 24 hrs by NCCLS M7-A5 based agar dilution method | ChEMBL. | 21937152 |
MIC (functional) | = 23.5 uM | Antituberculosis activity against 10'7 cfu/mL Mycobacterium tuberculosis H37Rv after 28 days | ChEMBL. | 21937152 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.