Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Tyrosine kinase homolog | 0.0141 | 0.228 | 1 |
Chlamydia trachomatis | peptide deformylase | 0.0228 | 0.3795 | 0.5 |
Brugia malayi | Hint module family protein | 0.0159 | 0.2599 | 1 |
Brugia malayi | Frizzled/Smoothened family membrane region containing protein | 0.0016 | 0.0117 | 0.0449 |
Schistosoma mansoni | frizzled-like receptor | 0.0016 | 0.0117 | 0.0161 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0087 | 0.1349 | 0.5 |
Echinococcus multilocularis | frizzled 5 | 0.0016 | 0.0117 | 0.0117 |
Echinococcus granulosus | frizzled 5 | 0.0016 | 0.0117 | 0.0117 |
Echinococcus multilocularis | frizzled | 0.0016 | 0.0117 | 0.0117 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0151 | 0.2453 | 0.4178 |
Echinococcus granulosus | frizzled | 0.0016 | 0.0117 | 0.0117 |
Toxoplasma gondii | hypothetical protein | 0.0228 | 0.3795 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0087 | 0.1349 | 0.5 |
Brugia malayi | Hint module family protein | 0.0159 | 0.2599 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0348 | 0.587 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0042 | 0.0561 | 0.5 |
Echinococcus granulosus | frizzled 4 | 0.0016 | 0.0117 | 0.0117 |
Echinococcus granulosus | twitchin | 0.0012 | 0.0041 | 0.0041 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.0501 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0087 | 0.1349 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.0015 | 0.0094 | 0.0094 |
Schistosoma mansoni | frizzled-like receptor | 0.0016 | 0.0117 | 0.0161 |
Echinococcus granulosus | smoothened | 0.0355 | 0.5997 | 0.5997 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0142 | 0.2295 | 0.8832 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0042 | 0.0561 | 0.0561 |
Echinococcus multilocularis | smoothened | 0.0355 | 0.5997 | 0.5997 |
Schistosoma mansoni | cell adhesion molecule | 0.0012 | 0.0052 | 0.0072 |
Treponema pallidum | polypeptide deformylase (def) | 0.0228 | 0.3795 | 0.5 |
Loa Loa (eye worm) | frizzled/Smoothened family membrane region containing protein | 0.0016 | 0.0117 | 0.0199 |
Schistosoma mansoni | hypothetical protein | 0.0427 | 0.724 | 1 |
Echinococcus granulosus | frizzled | 0.0016 | 0.0117 | 0.0117 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.2599 | 0.4428 |
Plasmodium vivax | peptide deformylase, putative | 0.0228 | 0.3795 | 1 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0087 | 0.1349 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.2599 | 0.4428 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0087 | 0.1349 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0228 | 0.3795 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0138 | 0.2226 | 0.2226 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0228 | 0.3795 | 0.5 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0042 | 0.0561 | 0.5 |
Schistosoma mansoni | nephrin | 0.0012 | 0.0041 | 0.0057 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0087 | 0.1349 | 0.5 |
Echinococcus multilocularis | frizzled 10 | 0.0016 | 0.0117 | 0.0117 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0094 | 0.0159 |
Echinococcus granulosus | neuroglian | 0.0012 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | frizzled/Smoothened family membrane region containing protein | 0.0016 | 0.0117 | 0.0199 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0151 | 0.2453 | 0.9437 |
Plasmodium falciparum | peptide deformylase | 0.0228 | 0.3795 | 1 |
Echinococcus granulosus | frizzled | 0.0016 | 0.0117 | 0.0117 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0142 | 0.2295 | 0.2295 |
Echinococcus multilocularis | hedgehog | 0.0586 | 1 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0038 | 0.0501 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0094 | 0.0159 |
Loa Loa (eye worm) | acetyltransferase | 0.0142 | 0.2295 | 0.391 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0087 | 0.1349 | 0.5 |
Schistosoma mansoni | frizzled | 0.0016 | 0.0117 | 0.0161 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0142 | 0.2295 | 0.317 |
Echinococcus multilocularis | frizzled 4 | 0.0016 | 0.0117 | 0.0117 |
Brugia malayi | Frizzled/Smoothened family membrane region containing protein | 0.0016 | 0.0117 | 0.0449 |
Mycobacterium ulcerans | peptide deformylase | 0.0228 | 0.3795 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0052 | 0.0089 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0228 | 0.3795 | 0.5 |
Echinococcus multilocularis | roundabout 2 | 0.0015 | 0.0094 | 0.0094 |
Echinococcus multilocularis | frizzled | 0.0016 | 0.0117 | 0.0117 |
Echinococcus multilocularis | neuroglian | 0.0012 | 0.0041 | 0.0041 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0012 | 0.0052 | 0.0052 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 138 uM | Inhibitory activity against class A Beta-lactamase TEM isolated from Enterobacter coli | ChEMBL. | 11012024 |
IC50 (binding) | = 138 uM | Inhibitory activity against class A Beta-lactamase TEM isolated from Enterobacter coli | ChEMBL. | 11012024 |
IC50 (binding) | = 246 uM | Inhibitory activity against class C Beta-lactamase isolated from Enterobacter cloacae | ChEMBL. | 11012024 |
IC50 (binding) | = 246 uM | Inhibitory activity against class C Beta-lactamase isolated from Enterobacter cloacae | ChEMBL. | 11012024 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.