Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0037 | 0.0349 | 0.0272 |
Brugia malayi | 6-phosphofructokinase | 0.0113 | 0.3238 | 0.4725 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.1327 | 0.2887 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0172 | 0.5531 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0038 | 0.0372 | 0.0094 |
Echinococcus granulosus | jun protein | 0.0172 | 0.5531 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0349 | 0.0272 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0145 | 0.4494 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0038 | 0.0372 | 0.5 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0113 | 0.3238 | 0.7247 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0169 | 0.5398 | 0.7918 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0349 | 0.0272 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.0344 | 0.9071 |
Trypanosoma brucei | glucosidase, putative | 0.0037 | 0.0349 | 0.0015 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0095 | 0.2549 | 0.1705 |
Brugia malayi | bZIP transcription factor family protein | 0.0172 | 0.5531 | 0.8115 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.0344 | 0.0447 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.0344 | 0.2354 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0038 | 0.0372 | 0.0295 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0095 | 0.2549 | 0.5535 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0038 | 0.0372 | 1 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0113 | 0.3238 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0113 | 0.3238 | 0.3185 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0038 | 0.0364 | 0.0586 |
Brugia malayi | hypothetical protein | 0.0135 | 0.4109 | 0.6013 |
Toxoplasma gondii | exonuclease III APE | 0.0038 | 0.0372 | 0.2566 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0169 | 0.5398 | 0.9757 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0113 | 0.3238 | 0.7179 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0113 | 0.3238 | 0.3185 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0038 | 0.0372 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0141 | 0.4327 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0141 | 0.4327 | 1 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0037 | 0.0349 | 0.0559 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0894 | 0.126 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0037 | 0.0349 | 0.0454 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0038 | 0.0364 | 0.0657 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.1327 | 0.2416 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0113 | 0.3238 | 0.3185 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0349 | 0.0272 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.1327 | 0.2468 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0085 | 0.2183 | 0.4618 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.0344 | 0.9174 |
Onchocerca volvulus | 0.0135 | 0.4109 | 0.5177 | |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0038 | 0.0372 | 0.0068 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.0344 | 0.9174 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0266 | 0.0332 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0037 | 0.0349 | 0.0272 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0037 | 0.0349 | 0.0631 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0095 | 0.2549 | 0.5535 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0095 | 0.2549 | 0.5535 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0113 | 0.3238 | 0.4921 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0349 | 0.0272 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0085 | 0.2183 | 0.4618 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0169 | 0.5398 | 0.9757 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0085 | 0.2183 | 0.4618 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0113 | 0.3238 | 0.3185 |
Echinococcus multilocularis | jun protein | 0.0172 | 0.5531 | 1 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0113 | 0.3238 | 0.5854 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0085 | 0.2183 | 0.4618 |
Mycobacterium tuberculosis | Probable reductase | 0.0085 | 0.2183 | 0.4618 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0113 | 0.3238 | 0.3185 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0169 | 0.5398 | 0.7918 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0113 | 0.3238 | 0.4725 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0169 | 0.5398 | 0.9759 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.003 | 0.0078 | 0.5 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0113 | 0.3238 | 0.3185 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0288 | 1 | 1 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.003 | 0.0078 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.1327 | 0.2342 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0113 | 0.3238 | 0.7179 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.1327 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0038 | 0.0372 | 0.0094 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0038 | 0.0372 | 0.0488 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.003 | 0.0078 | 0.0286 |
Brugia malayi | 6-phosphofructokinase | 0.0113 | 0.3238 | 0.4725 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0038 | 0.0372 | 0.0672 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0172 | 0.5531 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0038 | 0.0372 | 0.0741 |
Brugia malayi | phosphofructokinase | 0.0113 | 0.3238 | 0.4725 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.1327 | 0.2416 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0113 | 0.3238 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0894 | 0.126 |
Schistosoma mansoni | jun-related protein | 0.014 | 0.4291 | 0.9543 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0349 | 0.0015 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0266 | 0.0504 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.1327 | 0.2416 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.003 | 0.0078 | 0.0286 |
Loa Loa (eye worm) | phosphofructokinase | 0.0113 | 0.3238 | 0.4725 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0037 | 0.0349 | 0.0015 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0141 | 0.4327 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0349 | 0.2389 |
Brugia malayi | Pre-SET motif family protein | 0.0205 | 0.6807 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0113 | 0.3238 | 0.3185 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.0344 | 0.0447 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0113 | 0.3238 | 0.5823 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0038 | 0.0372 | 0.0295 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.003 | 0.0078 | 0.1115 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0038 | 0.0372 | 0.0601 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.1327 | 0.2887 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0085 | 0.2183 | 0.4618 |
Schistosoma mansoni | alpha glucosidase | 0.0037 | 0.0349 | 0.069 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0266 | 0.0332 |
Toxoplasma gondii | 6-phosphofructokinase | 0.003 | 0.0078 | 0.0286 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0349 | 0.0015 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0113 | 0.3238 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.1327 | 0.24 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.535 | 0.7846 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0205 | 0.6807 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0038 | 0.0372 | 0.0295 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0037 | 0.0349 | 0.0272 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0038 | 0.0372 | 0.0295 |
Schistosoma mansoni | hypothetical protein | 0.014 | 0.4291 | 0.9543 |
Brugia malayi | glutathione reductase | 0.0037 | 0.0344 | 0.0447 |
Onchocerca volvulus | 0.0098 | 0.2662 | 0.3335 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0894 | 0.126 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0038 | 0.0372 | 0.0094 |
Trichomonas vaginalis | set domain proteins, putative | 0.0234 | 0.7898 | 0.7881 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0038 | 0.0372 | 0.0094 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.0344 | 0.0447 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0894 | 0.126 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0113 | 0.3238 | 0.3185 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0038 | 0.0372 | 0.0295 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0349 | 0.0272 |
Onchocerca volvulus | 0.0234 | 0.7898 | 1 | |
Schistosoma mansoni | ap endonuclease | 0.0038 | 0.0372 | 0.0741 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0037 | 0.0349 | 0.0272 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0288 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0037 | 0.0349 | 0.0454 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.0344 | 0.9071 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0113 | 0.3238 | 0.4725 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0038 | 0.0372 | 0.0488 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.1327 | 0.3397 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0042 | 0.0075 |
Schistosoma mansoni | alpha-glucosidase | 0.0145 | 0.4494 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0349 | 0.0272 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0113 | 0.3238 | 0.7266 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.003 | 0.0078 | 0.1115 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0349 | 0.0272 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 86 uM | Growth inhibition of pro-apoptotic stimuli-sensitive mouse B16F10 cells after 72 hrs by MTT assay | ChEMBL. | 22019045 |
GI50 (functional) | > 100 uM | Growth inhibition of human MCF7 cells after 72 hrs by MTT assay | ChEMBL. | 22019045 |
GI50 (functional) | > 100 uM | Growth inhibition of pro-apoptotic stimuli-resistant human T98G cells after 72 hrs by MTT assay | ChEMBL. | 22019045 |
GI50 (functional) | > 100 uM | Growth inhibition of pro-apoptotic stimuli-resistant human A549 cells after 72 hrs by MTT assay | ChEMBL. | 22019045 |
GI50 (functional) | > 100 uM | Growth inhibition of pro-apoptotic stimuli-resistant human SK-MEL-28 cells after 72 hrs by MTT assay | ChEMBL. | 22019045 |
GI50 (functional) | > 100 uM | Growth inhibition of human PC3 cells after 72 hrs by MTT assay | ChEMBL. | 22019045 |
IC50 (functional) | > 100 uM | Antiplasmodial activity against Plasmodium falciparum F32-Tanzania after 24 hrs | ChEMBL. | 20627737 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.