Detailed information for compound 1148645

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 197.249 | Formula: C11H16FNO
  • H donors: 2 H acceptors: 1 LogP: 2.75 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCc1cc(cc(c1O)F)C(C)(C)C
  • InChi: 1S/C11H16FNO/c1-11(2,3)8-4-7(6-13)10(14)9(12)5-8/h4-5,14H,6,13H2,1-3H3
  • InChiKey: OKUCVWNVZIXZER-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans DNA polymerase IV 0.002 0.1035 0.5
Echinococcus granulosus expressed protein 0.0049 0.9382 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.1035 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.1035 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.5371 0.5371
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.1035 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.1035 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.1035 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.1035 0.1035
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.1035 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.1035 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.1035 0.5
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.1035 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 1 1
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.9382 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.1035 0.5
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.1035 0.5
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.1035 0.5
Toxoplasma gondii TIM10 family protein, putative 0.0049 0.9382 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.1035 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.1035 0.1035
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.1035 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.5371 0.5371
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.1035 0.5
Leishmania major DNA polymerase eta, putative 0.002 0.1035 0.5
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.1035 0.1103
Giardia lamblia DINP protein human, muc B family 0.002 0.1035 0.5
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.1035 0.1103
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.1035 0.5
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.1035 0.1103
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.1035 0.5
Echinococcus multilocularis dna polymerase eta 0.002 0.1035 0.1103
Schistosoma mansoni hypothetical protein 0.0035 0.5371 0.5725
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.9382 0.5
Leishmania major DNA polymerase kappa, putative 0.002 0.1035 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.1035 0.5
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0049 0.9382 0.9382
Loa Loa (eye worm) hypothetical protein 0.002 0.1035 0.1035
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.1035 0.5
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0049 0.9382 1
Schistosoma mansoni DNA polymerase eta 0.002 0.1035 0.1103
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.1035 0.5
Mycobacterium ulcerans DNA polymerase IV 0.002 0.1035 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 1 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.1035 0.1103
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.1035 0.1035
Trypanosoma brucei unspecified product 0.002 0.1035 0.5
Echinococcus granulosus dna polymerase kappa 0.002 0.1035 0.1103
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0049 0.9382 0.9382
Echinococcus multilocularis expressed protein 0.0049 0.9382 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.1035 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.1035 0.5
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.1035 0.1103
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.1035 0.5
Echinococcus granulosus dna polymerase eta 0.002 0.1035 0.1103
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.1035 0.5
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.9382 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.1035 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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