Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | 0.0033 | 0.4352 | 0.4698 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0033 | 0.4352 | 0.4352 |
Brugia malayi | hypothetical protein | 0.0028 | 0.3027 | 0.3027 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.089 | 0.089 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.089 | 0.0961 |
Brugia malayi | steroid hormone receptor | 0.0033 | 0.4352 | 0.4352 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4352 | 0.4352 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.9264 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0033 | 0.4352 | 0.4352 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0017 | 0.0116 | 0.0125 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.3027 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.3027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4352 | 0.4352 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.089 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0033 | 0.4352 | 0.4698 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.9264 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.9264 | 1 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0116 | 0.0116 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.9264 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.9264 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.9264 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0033 | 0.4352 | 0.4698 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0033 | 0.4352 | 0.4352 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.089 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.3027 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.089 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0033 | 0.4352 | 0.4698 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0116 | 0.0116 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0033 | 0.4352 | 0.4698 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0033 | 0.4352 | 0.4698 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.089 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.089 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.3027 | 0.3027 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.3027 | 1 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0314 | 0.0314 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.3027 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0017 | 0.0116 | 0.0125 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.089 | 0.0961 |
Brugia malayi | ecdysteroid receptor | 0.0033 | 0.4352 | 0.4352 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.089 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0033 | 0.4352 | 0.4698 |
Schistosoma mansoni | thyroid hormone receptor | 0.0033 | 0.4352 | 0.4698 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0033 | 0.4352 | 0.4352 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0033 | 0.4352 | 0.4698 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0033 | 0.4352 | 0.4698 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0033 | 0.4352 | 0.4352 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0033 | 0.4352 | 0.4698 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0116 | 0.0116 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0033 | 0.4352 | 0.4698 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0116 | 0.0116 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0033 | 0.4352 | 0.4352 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0033 | 0.4352 | 0.4698 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0033 | 0.4352 | 0.4352 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0017 | 0.0116 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4352 | 0.4352 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0033 | 0.4352 | 0.4352 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0033 | 0.4352 | 0.4352 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0033 | 0.4352 | 0.4698 |
Schistosoma mansoni | nuclear hormone receptor | 0.0033 | 0.4352 | 0.4698 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.089 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.9264 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0033 | 0.4352 | 0.4352 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4352 | 0.4352 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.089 | 0.0961 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0033 | 0.4352 | 0.4698 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0033 | 0.4352 | 0.4698 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0033 | 0.4352 | 0.4698 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0033 | 0.4352 | 0.4352 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0116 | 0.0116 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0033 | 0.4352 | 0.4352 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0033 | 0.4352 | 0.4698 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0017 | 0.0116 | 0.0116 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0033 | 0.4352 | 0.4352 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0017 | 0.0116 | 0.0116 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0033 | 0.4352 | 0.4698 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.5371 | 0.5798 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.9264 | 0.9264 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0033 | 0.4352 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0033 | 0.4352 | 0.4698 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0033 | 0.4352 | 0.4352 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.089 | 0.0961 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0033 | 0.4352 | 0.4352 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4352 | 0.4352 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.089 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.9264 | 0.9264 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0033 | 0.4352 | 0.4698 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0033 | 0.4352 | 0.4352 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.089 | 0.089 |
Onchocerca volvulus | 0.0033 | 0.4352 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4352 | 0.4352 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0017 | 0.0116 | 0.0125 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0017 | 0.0116 | 0.0125 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0033 | 0.4352 | 0.4352 |
Schistosoma mansoni | coup transcription factor | 0.0033 | 0.4352 | 0.4698 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.3027 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0033 | 0.4352 | 0.4352 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0033 | 0.4352 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0033 | 0.4352 | 0.4352 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.5371 | 0.5371 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0033 | 0.4352 | 0.4698 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4352 | 0.4352 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.5371 | 0.5371 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0033 | 0.4352 | 0.4352 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0033 | 0.4352 | 0.4352 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0033 | 0.4352 | 0.4698 |
Echinococcus granulosus | FTZ F1 alpha | 0.0033 | 0.4352 | 0.4698 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.3027 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0017 | 0.0116 | 0.0116 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0033 | 0.4352 | 0.4698 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0116 | 0.0116 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0033 | 0.4352 | 0.4698 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0033 | 0.4352 | 0.4698 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4352 | 0.4352 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0033 | 0.4352 | 0.4352 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0033 | 0.4352 | 0.4352 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0033 | 0.4352 | 0.4698 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0033 | 0.4352 | 0.4352 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0033 | 0.4352 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0116 | 0.0116 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.3027 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0033 | 0.4352 | 0.4698 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0033 | 0.4352 | 0.4352 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0033 | 0.4352 | 0.4352 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.