Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | glutamine binding protein | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0091 | 0.4666 | 0.3536 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0091 | 0.4666 | 0.1439 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0082 | 0.377 | 0.245 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0144 | 1 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0125 | 0.8068 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0045 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0045 | 0 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0045 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 86 mg kg-1 | Inhibition against writhing induced by Phenylbenzoquinone in male swiss albino mice | ChEMBL. | 3263504 |
ED50 (functional) | = 86 mg kg-1 | Inhibition against writhing induced by Phenylbenzoquinone in male swiss albino mice | ChEMBL. | 3263504 |
Inhibition (functional) | = 15 % | Inhibition against adjuvant-induced paw edema at a dose of 25 mg/kg in male Sprague-Dawley rats. | ChEMBL. | 3263504 |
logP (ADMET) | = 5.6 | Partition coefficient (logP) | ChEMBL. | 3263504 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.