Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0054 | 0.0224 | 0.0224 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0082 | 0.0523 | 0.0392 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0519 | 0.0388 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0082 | 0.0523 | 0.0523 |
Brugia malayi | thymidylate synthase | 0.0116 | 0.0883 | 0.0883 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0515 | 0.5153 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0969 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0116 | 0.0883 | 0.0883 |
Brugia malayi | Protein kinase domain containing protein | 0.0082 | 0.0523 | 0.0523 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0515 | 0.5153 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0174 | 0.1508 | 0.1508 |
Brugia malayi | jmjC domain containing protein | 0.0054 | 0.0224 | 0.0224 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0515 | 0.5153 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0054 | 0.0224 | 0.0224 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0116 | 0.0883 | 0.0883 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0054 | 0.0224 | 0.0089 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0054 | 0.0224 | 0.0224 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0969 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0969 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0174 | 0.1508 | 0.1508 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0054 | 0.0224 | 0.0224 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0116 | 0.0883 | 0.0664 |
Entamoeba histolytica | protein kinase, putative | 0.0082 | 0.0523 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0969 | 1 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0082 | 0.0523 | 0.0587 |
Onchocerca volvulus | 0.0116 | 0.0883 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0519 | 0.0388 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0046 | 0.0136 | 0.0136 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0515 | 0.5153 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0969 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0174 | 0.1508 | 0.1508 |
Entamoeba histolytica | protein kinase, putative | 0.0082 | 0.0523 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0174 | 0.1508 | 0.1508 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0174 | 0.1508 | 0.1508 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0046 | 0.0136 | 0.0136 |
Entamoeba histolytica | hypothetical protein | 0.0082 | 0.0523 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0054 | 0.0224 | 0.0224 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0054 | 0.0224 | 0.0224 |
Schistosoma mansoni | P2X receptor subunit | 0.0174 | 0.1508 | 0.1508 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0054 | 0.0224 | 0.0224 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0969 | 1 | 0.5 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0082 | 0.0523 | 0.0587 |
Brugia malayi | hypothetical protein | 0.0055 | 0.0235 | 0.0235 |
Schistosoma mansoni | P2X receptor subunit | 0.0174 | 0.1508 | 0.1508 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0055 | 0.0235 | 0.5 |
Echinococcus multilocularis | dual specificity | 0.0082 | 0.0523 | 0.0523 |
Echinococcus granulosus | dual specificity | 0.0082 | 0.0523 | 0.0523 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0174 | 0.1508 | 0.1508 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0515 | 0.5153 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0969 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0515 | 0.5153 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0969 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0174 | 0.1508 | 0.1508 |
Loa Loa (eye worm) | thymidylate synthase | 0.0116 | 0.0883 | 0.0757 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0174 | 0.1508 | 0.1508 |
Echinococcus granulosus | thymidylate synthase | 0.0116 | 0.0883 | 0.0883 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0969 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0054 | 0.0224 | 0.0224 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0082 | 0.0523 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 51.1 uM | Inhibition of Phenylethylamine N-Methyltransferase (PNMT) using radiochemical assay | ChEMBL. | 3681889 |
Ki (binding) | = 51.1 uM | Inhibition of Phenylethylamine N-Methyltransferase (PNMT) using radiochemical assay | ChEMBL. | 3681889 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.