Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | phospholipase A1, putative | 0.0357 | 0.4879 | 1 |
Trypanosoma cruzi | phospholipase A1, putative | 0.0357 | 0.4879 | 1 |
Trypanosoma brucei | phospholipase A1, putative | 0.0357 | 0.4879 | 0.5 |
Loa Loa (eye worm) | platelet-activating factor acetylhydrolase | 0.0357 | 0.4879 | 0.5 |
Leishmania major | phospholipase A1, putative | 0.0357 | 0.4879 | 0.5 |
Brugia malayi | Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein | 0.0357 | 0.4879 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 1.2 mg kg-1 | Inhibition against writhing induced by Phenylbenzoquinone in male swiss albino mice | ChEMBL. | 3263504 |
ED50 (functional) | = 1.2 mg kg-1 | Inhibition against writhing induced by Phenylbenzoquinone in male swiss albino mice | ChEMBL. | 3263504 |
IC50 (functional) | = 0.000000011 M | Inhibitory activity against prostaglandin biosynthesis in stimulated chondrocyte cell culture | ChEMBL. | 3263504 |
Inhibition (functional) | = 49 % | Inhibition against adjuvant-induced paw edema at a dose of 25 mg/kg in male Sprague-Dawley rats. | ChEMBL. | 3263504 |
logP (ADMET) | = 6.2 | Partition coefficient (logP) | ChEMBL. | 3263504 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.