Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0012 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0047 | 0.0047 |
Schistosoma mansoni | DNA polymerase eta | 0.0044 | 0.0211 | 0.1697 |
Echinococcus granulosus | geminin | 0.0168 | 0.1183 | 0.1172 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0047 | 0.0047 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0044 | 0.0211 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0012 | 0.0119 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0047 | 0.0449 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0012 | 0.0012 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0012 | 0.0012 |
Brugia malayi | hypothetical protein | 0.015 | 0.104 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0047 | 0.1731 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0012 | 0.0012 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0047 | 0.0047 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0047 | 0.0335 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0044 | 0.0211 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0044 | 0.0211 | 0.0199 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0047 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.1183 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0047 | 0.0047 |
Leishmania major | DNA polymerase eta, putative | 0.0044 | 0.0211 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0047 | 0.0449 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0012 | 0.0012 |
Onchocerca volvulus | 0.015 | 0.104 | 1 | |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0031 | 0.0107 | 0.4775 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0047 | 0.0335 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0047 | 0.0047 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.0365 | 0.2724 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0031 | 0.0107 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0047 | 0.0047 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0047 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0211 | 0.2028 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.0047 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0031 | 0.0107 | 0.4775 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0012 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0047 | 0.0449 |
Echinococcus multilocularis | thymidine phosphorylase | 0.1291 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0047 | 0.1731 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0047 | 0.1731 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.1291 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0047 | 0.0047 |
Mycobacterium tuberculosis | Probable anthranilate phosphoribosyltransferase TrpD | 0.0365 | 0.2724 | 0.2724 |
Mycobacterium ulcerans | anthranilate phosphoribosyltransferase | 0.0365 | 0.2724 | 0.2724 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.1291 | 1 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0168 | 0.1183 | 0.1172 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0047 | 0.0047 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0047 | 0.0335 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0044 | 0.0211 | 0.1933 |
Echinococcus granulosus | dna polymerase eta | 0.0044 | 0.0211 | 0.0199 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.1183 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0012 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.104 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MED (functional) | <= 3.2 mg kg-1 | Minimal effective dose in an rat anti-immobility effect using behavioral despair test | ChEMBL. | 2374150 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.