Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | endothelin receptor type B | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0057 | 0.3967 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0057 | 0.3967 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0057 | 0.3967 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0057 | 0.3967 | 0.3967 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0057 | 0.3967 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0057 | 0.3967 | 0.3967 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0057 | 0.3967 | 0.3967 |
Echinococcus granulosus | FTZ F1 alpha | 0.0057 | 0.3967 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0057 | 0.3967 | 0.3967 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0057 | 0.3967 | 0.3967 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0057 | 0.3967 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0057 | 0.3967 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.3967 | 0.3967 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0057 | 0.3967 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0057 | 0.3967 | 0.3967 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0057 | 0.3967 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0057 | 0.3967 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0057 | 0.3967 | 0.3967 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0057 | 0.3967 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0057 | 0.3967 | 0.3967 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0057 | 0.3967 | 0.3967 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.3967 | 0.3967 |
Brugia malayi | ecdysteroid receptor | 0.0057 | 0.3967 | 0.3967 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.3967 | 0.3967 |
Brugia malayi | nuclear hormone receptor | 0.0057 | 0.3967 | 0.3967 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0057 | 0.3967 | 0.3967 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0057 | 0.3967 | 0.3967 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.3967 | 0.3967 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0057 | 0.3967 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0057 | 0.3967 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0057 | 0.3967 | 0.3967 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0057 | 0.3967 | 0.3967 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0057 | 0.3967 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0057 | 0.3967 | 0.3967 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0057 | 0.3967 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0057 | 0.3967 | 0.3967 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.3967 | 0.3967 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0057 | 0.3967 | 0.3967 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0098 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0057 | 0.3967 | 0.3967 |
Schistosoma mansoni | coup transcription factor | 0.0057 | 0.3967 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0057 | 0.3967 | 0.3967 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0057 | 0.3967 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0057 | 0.3967 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0057 | 0.3967 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0057 | 0.3967 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0057 | 0.3967 | 0.3967 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0057 | 0.3967 | 0.3967 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0057 | 0.3967 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.3967 | 0.3967 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0057 | 0.3967 | 0.3967 |
Brugia malayi | nuclear receptor NHR-88 | 0.0057 | 0.3967 | 0.3967 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.3967 | 0.3967 |
Onchocerca volvulus | 0.0057 | 0.3967 | 0.5 | |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0057 | 0.3967 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0057 | 0.3967 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0057 | 0.3967 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0057 | 0.3967 | 0.3967 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0057 | 0.3967 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0057 | 0.3967 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0057 | 0.3967 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0057 | 0.3967 | 0.3967 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0057 | 0.3967 | 0.3967 |
Schistosoma mansoni | thyroid hormone receptor | 0.0057 | 0.3967 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.3967 | 0.3967 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0057 | 0.3967 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0057 | 0.3967 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0057 | 0.3967 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0057 | 0.3967 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0057 | 0.3967 | 0.3967 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0057 | 0.3967 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0057 | 0.3967 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.77 uM | Receptor binding affinity was determined against [125I]-ET-1 with membranes prepared from human placenta for ETB receptor | ChEMBL. | No reference |
IC50 (binding) | = 0.77 uM | Receptor binding affinity was determined against [125I]-ET-1 with membranes prepared from human placenta for ETB receptor | ChEMBL. | No reference |
IC50 (binding) | = 0.88 uM | Receptor binding affinity was determined against [125I]-ET-1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells | ChEMBL. | No reference |
IC50 (binding) | = 0.88 uM | Receptor binding affinity was determined against [125I]-ET-1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.