Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.6833 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0897 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0418 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0897 | 0.1313 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0897 | 0.1313 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0897 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0418 | 1 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0021 | 0.0021 |
Onchocerca volvulus | 0.0264 | 1 | 1 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0897 | 0.1311 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0186 | 0.6844 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0897 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0418 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0418 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.6833 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.4606 | 0.4606 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0418 | 1 |
Schistosoma mansoni | jun-related protein | 0.0151 | 0.543 | 0.7947 |
Brugia malayi | hypothetical protein | 0.0146 | 0.5223 | 0.5223 |
Echinococcus multilocularis | geminin | 0.0186 | 0.6833 | 0.9984 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0186 | 0.6844 | 1 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0264 | 1 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0186 | 0.6844 | 0.6844 |
Echinococcus granulosus | jun protein | 0.0186 | 0.6844 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0418 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.6637 | 0.6637 |
Schistosoma mansoni | hypothetical protein | 0.0151 | 0.543 | 0.7947 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0897 | 0.1311 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.4606 | 0.4606 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0418 | 1 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0897 | 0.0897 |
Echinococcus granulosus | geminin | 0.0186 | 0.6833 | 0.9984 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.4606 | 0.4606 |
Echinococcus multilocularis | jun protein | 0.0186 | 0.6844 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0418 | 0.0418 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0418 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0897 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 25 % | Evaluation for percent inhibition of prostaglandin G/H synthase 2 in human whole blood (HWB) at a concentration of 1 um | ChEMBL. | 15084117 |
Inhibition (binding) | = 25 % | Evaluation for percent inhibition of prostaglandin G/H synthase 2 in human whole blood (HWB) at a concentration of 1 um | ChEMBL. | 15084117 |
Inhibition (binding) | = 50 % | Percentage inhibition of prostaglandin G/H synthase 1 in human whole blood (HWB) at a concentration of 100 um | ChEMBL. | 15084117 |
Inhibition (binding) | = 50 % | Percentage inhibition of prostaglandin G/H synthase 1 in human whole blood (HWB) at a concentration of 100 um | ChEMBL. | 15084117 |
Inhibition (binding) | = 85 % | Evaluation for percent inhibition of prostaglandin G/H synthase 2 in human whole blood (HWB) at a concentration of 10 um | ChEMBL. | 15084117 |
Inhibition (binding) | = 85 % | Evaluation for percent inhibition of prostaglandin G/H synthase 2 in human whole blood (HWB) at a concentration of 10 um | ChEMBL. | 15084117 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.