Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | caspase 2 | 0.0126 | 0.84 | 1 |
Trypanosoma brucei | metacaspase MCA2 | 0.0038 | 0 | 0.5 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0038 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0126 | 0.84 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.0038 | 0 | 0.5 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0038 | 0 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0038 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0038 | 0 | 0.5 |
Trypanosoma brucei | metacaspase | 0.0038 | 0 | 0.5 |
Plasmodium falciparum | metacaspase 1 | 0.0038 | 0 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0038 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.4792 | 0.4792 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0038 | 0 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.0038 | 0 | 0.5 |
Trypanosoma brucei | metacaspase 5, putative | 0.0038 | 0 | 0.5 |
Brugia malayi | Cell death protein 3 precursor | 0.0126 | 0.84 | 0.84 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0038 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0088 | 0.4792 | 0.5705 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0088 | 0.4792 | 0.5705 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0143 | 1 | 1 |
Echinococcus granulosus | caspase 2 | 0.0126 | 0.84 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0038 | 0 | 0.5 |
Trypanosoma brucei | metacaspase MCA3 | 0.0038 | 0 | 0.5 |
Trypanosoma brucei | Metacaspase-4 | 0.0038 | 0 | 0.5 |
Plasmodium falciparum | metacaspase-like protein | 0.0038 | 0 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0088 | 0.4792 | 0.5705 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0038 | 0 | 0.5 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0126 | 0.84 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0038 | 0 | 0.5 |
Plasmodium vivax | metacaspase 1, putative | 0.0038 | 0 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0038 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0 | 0.5 |
Leishmania major | metacaspase, putative | 0.0038 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0088 | 0.4792 | 0.4792 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.84 | 0.84 |
Trypanosoma cruzi | metacaspase, putative | 0.0038 | 0 | 0.5 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0038 | 0 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0038 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.