Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0972 | 0.1996 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.4286 | 0.4286 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.4286 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.4012 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0972 | 0.1996 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0972 | 0.0972 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.4012 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0053 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.4286 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0972 | 0.0426 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0972 | 0.1996 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.4012 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.4286 | 1 |
Brugia malayi | hypothetical protein | 0.0019 | 0.1274 | 0.0745 |
Onchocerca volvulus | 0.0031 | 0.4286 | 0.5 | |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0972 | 0.0426 |
Echinococcus multilocularis | musashi | 0.0031 | 0.4286 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0146 | 0.0146 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.4286 | 0.4286 |
Echinococcus granulosus | lamin | 0.0031 | 0.4286 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0972 | 0.1996 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0972 | 0.1996 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.4012 | 1 |
Schistosoma mansoni | lamin | 0.0031 | 0.4286 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.4012 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.4139 | 0.4139 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.4286 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.4012 | 0.4012 |
Onchocerca volvulus | 0.0031 | 0.4286 | 0.5 | |
Echinococcus multilocularis | lamin | 0.0031 | 0.4286 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0972 | 0.1996 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.4286 | 0.394 |
Schistosoma mansoni | lamin | 0.0031 | 0.4286 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.4286 | 0.4286 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.4012 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0571 | 0.0571 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.4012 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0972 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.4286 | 0.394 |
Brugia malayi | hypothetical protein | 0.003 | 0.4012 | 0.365 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.4012 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.