Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0167 | 0.1296 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 1 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0024 | 0.0126 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0167 | 0.1296 |
Plasmodium falciparum | thioredoxin reductase | 0.0069 | 0.129 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0449 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0024 | 0.0126 | 0.0976 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0069 | 0.129 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0167 | 0.1296 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0024 | 0.0126 | 0.0976 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0024 | 0.0126 | 0.0976 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0024 | 0.0126 | 1 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0024 | 0.0126 | 0.0976 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0024 | 0.0126 | 0.0976 |
Plasmodium falciparum | glutathione reductase | 0.0069 | 0.129 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0069 | 0.129 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0024 | 0.0126 | 0.032 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0069 | 0.129 | 0.129 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0024 | 0.0126 | 0.0976 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0024 | 0.0126 | 0.0976 |
Toxoplasma gondii | thioredoxin reductase | 0.0069 | 0.129 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0024 | 0.0126 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0167 | 0.0167 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0024 | 0.0126 | 0.0976 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0024 | 0.0126 | 0.0976 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0024 | 0.0126 | 0.0976 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.3936 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0024 | 0.0126 | 0.0976 |
Leishmania major | trypanothione reductase | 0.0069 | 0.129 | 1 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0024 | 0.0126 | 0.0976 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0024 | 0.0126 | 0.032 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0449 | 0.114 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0449 | 0.0449 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0024 | 0.0126 | 0.0976 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0024 | 0.0126 | 0.032 |
Loa Loa (eye worm) | glutathione reductase | 0.0069 | 0.129 | 0.129 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0449 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0024 | 0.0126 | 0.0976 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0167 | 0.1296 |
Plasmodium falciparum | glutathione reductase | 0.0024 | 0.0126 | 0.0976 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0024 | 0.0126 | 0.0976 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0024 | 0.0126 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0449 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0449 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0024 | 0.0126 | 0.0976 |
Treponema pallidum | NADH oxidase | 0.0024 | 0.0126 | 1 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0024 | 0.0126 | 0.0976 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0024 | 0.0126 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0167 | 0.0167 |
Brugia malayi | Fibroblast growth factor family protein | 0.0404 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0069 | 0.129 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0167 | 0.1296 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0024 | 0.0126 | 0.0976 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0024 | 0.0126 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0167 | 0.1296 |
Echinococcus multilocularis | geminin | 0.0171 | 0.3936 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0024 | 0.0126 | 0.0976 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0167 | 0.1296 |
Plasmodium falciparum | thioredoxin reductase | 0.0024 | 0.0126 | 0.0976 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.286 | 0.286 |
Brugia malayi | Thioredoxin reductase | 0.0069 | 0.129 | 0.129 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0449 | 0.114 |
Brugia malayi | glutathione reductase | 0.0069 | 0.129 | 0.129 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0024 | 0.0126 | 0.0976 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.3936 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0024 | 0.0126 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0404 | 1 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0024 | 0.0126 | 0.0976 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0449 | 0.114 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0024 | 0.0126 | 0.0126 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0024 | 0.0126 | 0.0976 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0024 | 0.0126 | 0.0976 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0024 | 0.0126 | 0.0126 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0069 | 0.129 | 0.3278 |
Echinococcus granulosus | geminin | 0.0171 | 0.3936 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0024 | 0.0126 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0069 | 0.129 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0024 | 0.0126 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0449 | 0.114 |
Brugia malayi | Protein kinase domain containing protein | 0.0129 | 0.286 | 0.286 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0069 | 0.129 | 1 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0024 | 0.0126 | 0.0976 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0167 | 0.1296 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0024 | 0.0126 | 0.0976 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0069 | 0.129 | 0.3278 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0024 | 0.0126 | 0.0976 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0024 | 0.0126 | 0.0976 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.