Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0011 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.3465 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.3465 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.6532 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.6532 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.6532 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.6532 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.6532 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.1482 | 0.1482 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.3465 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0011 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0011 | 0 | 0.5 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.0011 | 0 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.1482 | 0.1482 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.1482 | 0.2269 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.6532 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.1967 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.3465 | 0.5305 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.3465 | 1 |
Giardia lamblia | Replication factor C, subunit 1 | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.1482 | 0.2269 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.3465 | 1 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 1 | 1 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0011 | 0 | 0.5 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0011 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.3465 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.3465 | 0.3465 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.1967 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.3465 | 1 |
Toxoplasma gondii | ATPase, AAA family protein | 0.0011 | 0 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.3465 | 1 |
Onchocerca volvulus | 0.0027 | 0.3465 | 1 | |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.0011 | 0 | 0.5 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0011 | 0 | 0.5 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.6532 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1967 | 0.1967 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.1482 | 0.2269 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.1482 | 0.1482 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.3465 | 0.3465 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.1482 | 0.2269 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1967 | 0.1967 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.1482 | 0.2269 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.3465 | 0.3465 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0011 | 0 | 0.5 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.6057 | 0.6057 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0027 | 0.3465 | 0.5305 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0011 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0041 | 0.6532 | 0.6532 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.3465 | 0.3465 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.6532 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.3465 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1967 | 0.1967 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.1482 | 0.2269 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1967 | 0.1967 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.1482 | 0.2269 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.3465 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1482 | 0.1482 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.3465 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.3465 | 0.3465 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.1482 | 0.2269 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0011 | 0 | 0.5 |
Treponema pallidum | DNA ligase (lig) | 0.0011 | 0 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.3465 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0011 | 0 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.1967 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.1482 | 0.2269 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.6057 | 0.9273 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.3465 | 0.3465 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.3465 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.1482 | 0.2269 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1967 | 0.1967 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.002 | 0.1967 | 0.5677 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0011 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.3465 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.6057 | 0.6057 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.3465 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.3465 | 0.5305 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.1967 | 0.139 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.