Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0006 | 0.0381 |
Schistosoma mansoni | DNA helicase recq1 | 0.0021 | 0.0148 | 0.0148 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0148 | 0.0549 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0006 | 0.00000000046184 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0062 | 0.0705 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0134 | 0.0513 |
Onchocerca volvulus | 0.0201 | 0.2606 | 0.5 | |
Leishmania major | hypothetical protein, conserved | 0.0062 | 0.0705 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0201 | 0.2606 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0201 | 0.2606 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0201 | 0.2606 | 1 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0201 | 0.2606 | 1 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0134 | 0.0134 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0201 | 0.2606 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0021 | 0.0148 | 0.057 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0021 | 0.0148 | 0.0015 |
Echinococcus multilocularis | bloom syndrome protein | 0.0021 | 0.0148 | 0.0015 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0021 | 0.0148 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0021 | 0.0148 | 0.0015 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.0148 | 0.0261 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0201 | 0.2606 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0021 | 0.0148 | 0.006 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0021 | 0.0148 | 0.006 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0134 | 0.183 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.0148 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.0148 | 1 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0201 | 0.2606 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0011 | 0.0006 | 0.0006 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0011 | 0.0006 | 0.0423 |
Schistosoma mansoni | DNA helicase recq5 | 0.0021 | 0.0148 | 0.0148 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.0148 | 0.2043 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0062 | 0.0705 | 1 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0201 | 0.2606 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0021 | 0.0148 | 0.006 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0134 | 0.8998 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0201 | 0.2606 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.0148 | 0.0261 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.0148 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0134 | 0.183 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0062 | 0.0705 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0021 | 0.0148 | 0.0549 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0201 | 0.2606 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0021 | 0.0148 | 0.0015 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0134 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0021 | 0.0148 | 0.0549 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0021 | 0.0148 | 0.006 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0062 | 0.0705 | 0.2309 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0134 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0134 | 0.5 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.0148 | 0.006 |
Entamoeba histolytica | recQ family DNA helicase | 0.0011 | 0.0006 | 0.0022 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0201 | 0.2606 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.0148 | 0.006 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0134 | 0.0492 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0139 | 0.1759 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0021 | 0.0148 | 0.006 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0021 | 0.0148 | 0.0015 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0201 | 0.2606 | 1 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0134 | 0.0134 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0062 | 0.0705 | 0.2309 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0021 | 0.0148 | 0.0015 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.