Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0076 | 0.0024 | 0.0024 |
Echinococcus granulosus | pyruvate kinase | 0.1296 | 0.4995 | 0.4995 |
Echinococcus multilocularis | pyruvate kinase | 0.1993 | 0.7833 | 0.7833 |
Mycobacterium ulcerans | glutaminase | 0.0293 | 0.0911 | 0.0889 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0109 | 0.0161 | 0.0161 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0109 | 0.0161 | 0.0161 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0024 | 0.0024 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0789 | 0.293 | 0.293 |
Brugia malayi | pyruvate kinase | 0.0532 | 0.1883 | 0.1883 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0024 | 0.0024 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0076 | 0.0024 | 0.0024 |
Echinococcus granulosus | pyruvate kinase | 0.1296 | 0.4995 | 0.4995 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0109 | 0.0161 | 0.0161 |
Brugia malayi | beta-lactamase family protein | 0.0076 | 0.0024 | 0.0024 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0076 | 0.0024 | 0.0024 |
Echinococcus multilocularis | pyruvate kinase | 0.1296 | 0.4995 | 0.4995 |
Echinococcus multilocularis | geminin | 0.0205 | 0.055 | 0.055 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0076 | 0.0024 | 0.0024 |
Echinococcus granulosus | pyruvate kinase | 0.1296 | 0.4995 | 0.4995 |
Echinococcus granulosus | geminin | 0.0205 | 0.055 | 0.055 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0024 | 0.0024 |
Entamoeba histolytica | hypothetical protein | 0.0109 | 0.0161 | 0.0234 |
Entamoeba histolytica | hypothetical protein | 0.0109 | 0.0161 | 0.0234 |
Entamoeba histolytica | pyruvate kinase, putative | 0.1761 | 0.6888 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.1296 | 0.4995 | 0.4995 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0483 | 0.1683 | 0.1663 |
Echinococcus multilocularis | pyruvate kinase | 0.1296 | 0.4995 | 0.4995 |
Loa Loa (eye worm) | glutaminase 2 | 0.0293 | 0.0911 | 0.0911 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.055 | 0.055 |
Loa Loa (eye worm) | hypothetical protein | 0.1761 | 0.6888 | 0.6888 |
Trichomonas vaginalis | glutaminase, putative | 0.0293 | 0.0911 | 0.0889 |
Brugia malayi | hypothetical protein | 0.0109 | 0.0161 | 0.0161 |
Brugia malayi | beta-lactamase | 0.0076 | 0.0024 | 0.0024 |
Plasmodium vivax | pyruvate kinase 2, putative | 0.1296 | 0.4995 | 0.4983 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0076 | 0.0024 | 0.0024 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0076 | 0.0024 | 0.0024 |
Toxoplasma gondii | pyruvate kinase PyKII | 0.1296 | 0.4995 | 0.4983 |
Loa Loa (eye worm) | beta-lactamase | 0.0076 | 0.0024 | 0.0024 |
Brugia malayi | pyruvate kinase, muscle isozyme | 0.0532 | 0.1883 | 0.1883 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0076 | 0.0024 | 0.0024 |
Entamoeba histolytica | hypothetical protein | 0.0109 | 0.0161 | 0.0234 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0076 | 0.0024 | 0.0024 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0076 | 0.0024 | 0.0024 |
Brugia malayi | glutaminase DH11.1 | 0.0293 | 0.0911 | 0.0911 |
Leishmania major | hypothetical protein, conserved | 0.0076 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | pyruvate kinase | 0.0532 | 0.1883 | 0.1883 |
Schistosoma mansoni | glutaminase | 0.0293 | 0.0911 | 0.0911 |
Entamoeba histolytica | hypothetical protein | 0.0109 | 0.0161 | 0.0234 |
Loa Loa (eye worm) | glutaminase | 0.0293 | 0.0911 | 0.0911 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0024 | 0.0024 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.055 | 0.055 |
Brugia malayi | beta-lactamase family protein | 0.0076 | 0.0024 | 0.0024 |
Schistosoma mansoni | pyruvate kinase | 0.1296 | 0.4995 | 0.4995 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.1761 | 0.6888 | 0.6888 |
Brugia malayi | Pyruvate kinase, alpha/beta domain containing protein | 0.0764 | 0.2828 | 0.2828 |
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.0161 | 0.0161 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.636 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.3323 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 7.3078 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.